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Tchem
EHMT1
Histone-lysine N-methyltransferase EHMT1

Protein Summary
Description
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This act ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371394
  • ENSP00000485945
  • ENSG00000181090
  • ENST00000460843
  • ENSP00000417980
  • ENST00000462484
  • ENSP00000417328

Symbol
  • EUHMTASE1
  • GLP
  • KIAA1876
  • KMT1D
  • GLP
  • GLP1
  • KMT1D
  • KLEFS1
  • FP13812
  • EHMT1-IT1
  • EUHMTASE1
  • Eu-HMTase1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
molecular function
0.81
protein domain
0.73
histone modification site profile
0.72
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.01   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 483   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.01   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 483   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Chromatin modifying enzymes
Chromatin organization
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (189)
1 – 10 of 189
XAGE3
Tdark
Novelty: 0.1418603
p_int: 0.999998883
p_ni: 0.000001117
Score: 0.167
Data Source: BioPlex,STRINGDB
XAGE2
Tbio
Novelty: 0.15338981
p_int: 0.999998453
p_ni: 0.000001547
Score: 0.187
Data Source: BioPlex,STRINGDB
ZNF462
Tbio
Novelty: 0.13731082
p_int: 0.999996651
p_ni: 0.000003349
Score: 0.324
Data Source: BioPlex,STRINGDB
RARRES1
Tbio
Family: Enzyme
Novelty: 0.04701793
p_int: 0.999782516
p_ni: 0.000217484
Data Source: BioPlex
MIER2
Tbio
Novelty: 0.85226416
p_int: 0.999729411
p_ni: 0.000270589
Score: 0.326
Data Source: BioPlex,STRINGDB
L3MBTL1
Tchem
Family: TF; Epigenetic
Novelty: 0.02321712
p_int: 0.99752907
p_ni: 0.00247093
Score: 0.48
Data Source: BioPlex,STRINGDB
ZBTB46
Tbio
Family: TF
Novelty: 0.04699856
p_int: 0.997172053
p_ni: 0.002827947
Score: 0.271
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.972886641
p_ni: 0.026591777
p_wrong: 0.000521582
Score: 0.446
Data Source: BioPlex,Reactome,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.971174549
p_ni: 0.028825451
Score: 0.67
Data Source: BioPlex,STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.958272656
p_ni: 0.041727344
Score: 0.57
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  115.01

PubMed score by year
PubTator Score  94.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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