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Tbio
MUC4
Mucin-4

Protein Summary
Description
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. The major constituents of mucus, the viscous secretion that covers epithelial ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.87
cellular component
0.74
cell line
0.67
PubMedID
0.61
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.05   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.05   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
1
1
1
69.1
glomerular filtration rate
1
1
0
5.6
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
1
69.1
glomerular filtration rate
0
5.6
7.9
Pathways (15)
C-type lectin receptors (CLRs) (R-HSA-5621481)

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Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Protein-Protein Interactions (120)
1 – 10 of 120
MUC16
Tbio
Novelty: 0.00444587
Score: 0.986
Data Source: STRINGDB
MUC1
Tbio
Novelty: 0.00024203
Score: 0.986
Data Source: STRINGDB
MUC6
Tbio
Novelty: 0.00304872
Score: 0.984
Data Source: STRINGDB
MUC20
Tbio
Novelty: 0.04645313
Score: 0.979
Data Source: STRINGDB
MUC13
Tbio
Novelty: 0.01282861
Score: 0.979
Data Source: STRINGDB
MUC7
Tbio
Novelty: 0.00750654
Score: 0.978
Data Source: STRINGDB
MUC15
Tbio
Novelty: 0.02213624
Score: 0.971
Data Source: STRINGDB
MUC21
Tbio
Novelty: 0.02583488
Score: 0.964
Data Source: STRINGDB
GALNT6
Tbio
Family: Enzyme
Novelty: 0.04627605
Score: 0.957
Data Source: STRINGDB
B3GNT5
Tbio
Family: Enzyme
Novelty: 0.08038327
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  561.05

PubMed score by year
PubTator Score  329.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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