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Tchem
FHIT
Bis(5'-adenosyl)-triphosphatase

Protein Classes
Protein Summary
Description
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000468189
  • ENSP00000417480
  • ENSG00000189283
  • ENST00000476844
  • ENSP00000417557
  • ENST00000492590
  • ENSP00000418582

Symbol
  • FRA3B
  • AP3Aase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
disease
0.91
histone modification site profile
0.85
transcription factor binding site profile
0.8
phenotype
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 866.88   (req: < 5)
Gene RIFs: 252   (req: <= 3)
Antibodies: 545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 866.88   (req: >= 5)
Gene RIFs: 252   (req: > 3)
Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
13
2
20
98.1
unipolar depression
2
2
0
3.6
95.6
testosterone measurement
3
2
4
93.8
smoking status measurement
2
4
4
88.9
depressive symptom measurement
2
2
1
6.2
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
20
98.1
unipolar depression
0
3.6
95.6
testosterone measurement
4
93.8
smoking status measurement
4
88.9
depressive symptom measurement
1
6.2
72.1
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (335)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
Small cell lung cancer
KEGG
Metabolic pathways
KEGG
Purine metabolism
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
Small cell lung cancer
Metabolic pathways
Purine metabolism
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (92)
1 – 10 of 92
ARHGAP19
Tbio
Family: Enzyme
Novelty: 0.19587262
p_int: 0.999476738
p_ni: 0.000523262
Score: 0.309
Data Source: BioPlex,STRINGDB
MTMR6
Tbio
Family: Enzyme
Novelty: 0.13067072
p_int: 0.993682701
p_ni: 0.006317285
p_wrong: 1.4e-8
Score: 0.345
Data Source: BioPlex,STRINGDB
RABL2A
Tbio
Family: Enzyme
Novelty: 0.09940618
p_int: 0.911219662
p_ni: 0.039078108
p_wrong: 0.04970223
Score: 0.318
Data Source: BioPlex,STRINGDB
WWOX
Tbio
Family: Enzyme
Novelty: 0.00335243
Score: 0.839
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.808
Data Source: STRINGDB
ENPP4
Tbio
Family: Enzyme
Novelty: 0.09897251
Score: 0.8
Data Source: STRINGDB
FDXR
Tbio
Family: Enzyme
Novelty: 0.00171588
Score: 0.791
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.77
Data Source: STRINGDB
HINT1
Tbio
Novelty: 0.00815168
Score: 0.75
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.75
Data Source: STRINGDB
Publication Statistics
PubMed Score  866.88

PubMed score by year
PubTator Score  657.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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