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Tdark
KRTAP5-7
Keratin-associated protein 5-7

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398536
  • ENSP00000417330
  • ENSG00000244411

Symbol
  • KAP5-7
  • KAP5.3
  • KRTAP5.3
  • KRTAP5.7
  • KRTAP5-3
  • KRTAP5.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.66
tissue
0.44
microRNA
0.27
cellular component
0.25
transcription factor
0.17


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.37   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.37   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin associated protein 5-6 [Source:HGNC Symbol;Acc:HGNC:23600]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin associated protein 5-6 [Source:HGNC Symbol;Acc:HGNC:23600]
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (84)
1 – 10 of 84
KRTAP5-2
Tdark
Novelty: 3.93025514
Score: 0.644
Data Source: STRINGDB
FAM47C
Tdark
Novelty: 0.91246076
Score: 0.58
Data Source: STRINGDB
KRTAP5-10
Tdark
Novelty: 6.40062041
Score: 0.578
Data Source: STRINGDB
KRTAP5-8
Tdark
Novelty: 3.93025514
Score: 0.568
Data Source: STRINGDB
KRTAP4-2
Tdark
Novelty: 0.63177537
Score: 0.529
Data Source: STRINGDB
KRTAP4-4
Tdark
Novelty: 10.96799259
Score: 0.525
Data Source: STRINGDB
KRTAP5-11
Tdark
Novelty: 51.19366197
Score: 0.516
Data Source: STRINGDB
ODF2L
Tdark
Novelty: 0.56986705
Score: 0.491
Data Source: STRINGDB
C6orf223
Tdark
Novelty: 0.63740066
Score: 0.479
Data Source: STRINGDB
FAM86C1
Tdark
Family: Enzyme
Novelty: 1.61781609
Score: 0.47
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.37

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer