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Tbio
FBLIM1
Filamin-binding LIM protein 1

Protein Summary
Description
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte dif ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332305
  • ENSP00000364920
  • ENSG00000162458
  • ENST00000375766
  • ENSP00000364921
  • ENST00000375771
  • ENSP00000364926
  • ENST00000441801
  • ENSP00000416387

Symbol
  • FBLP1
  • CAL
  • FBLP1
  • FBLP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor
0.71
PubMedID
0.65
cellular component
0.63
small molecule perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.38   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.38   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
88.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
filamin binding LIM protein 1
VGNC:1237
740207
Macaque
filamin binding LIM protein 1
695727
Mouse
MGI:1921452
74202
Rat
RGD:1359551
362650
Dog
filamin binding LIM protein 1
VGNC:40749
608618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
filamin binding LIM protein 1
Macaque
filamin binding LIM protein 1
Mouse
Rat
Dog
filamin binding LIM protein 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WUP2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (65)
1 – 10 of 65
DCLK1
Tchem
Family: Kinase
Novelty: 0.0064994
p_int: 0.99999991
p_ni: 9e-8
Data Source: BioPlex
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
p_int: 0.999999779
p_ni: 7.3e-8
p_wrong: 1.48e-7
Score: 0.318
Data Source: BioPlex,STRINGDB
KCTD3
Tdark
Novelty: 0.33599775
p_int: 0.999999645
p_ni: 3.56e-7
Data Source: BioPlex
SHKBP1
Tbio
Novelty: 0.00235279
p_int: 0.999999633
p_ni: 3.67e-7
Data Source: BioPlex
SHB
Tbio
Novelty: 0.00319675
p_int: 0.999999449
p_ni: 3.2e-8
p_wrong: 5.19e-7
Data Source: BioPlex
TMCC2
Tdark
Novelty: 0.21581357
p_int: 0.999999407
p_ni: 5.88e-7
p_wrong: 4e-9
Score: 0.202
Data Source: BioPlex,STRINGDB
DCLK2
Tchem
Family: Kinase
Novelty: 0.0731754
p_int: 0.999998522
p_ni: 1.6e-8
p_wrong: 0.000001461
Data Source: BioPlex
RFLNB
Tbio
Novelty: 0.09562879
p_int: 0.999997221
p_ni: 0.000002779
Data Source: BioPlex
NIF3L1
Tbio
Novelty: 0.15581813
p_int: 0.999995903
p_ni: 0.000004097
Data Source: BioPlex
DIXDC1
Tbio
Novelty: 0.05901474
p_int: 0.999993625
p_ni: 0.000006275
p_wrong: 1e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  34.38

PubMed score by year
PubTator Score  111.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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