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Tbio
TGFBI
Transforming growth factor-beta-induced protein ig-h3

Protein Classes
Protein Summary
Description
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442011
  • ENSP00000416330
  • ENSG00000120708

Symbol
  • BIGH3
  • CSD
  • CDB1
  • CDG2
  • CSD1
  • CSD2
  • CSD3
  • EBMD
  • LCD1
  • BIGH3
  • CDGG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
virus perturbation
0.97
gene perturbation
0.96
biological term
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 672.13   (req: < 5)
Gene RIFs: 197   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 672.13   (req: >= 5)
Gene RIFs: 197   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
1
0
1.1
35.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1.1
35.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta induced
VGNC:4194
462081
Macaque
transforming growth factor beta induced
712503
Mouse
MGI:99959
21810
Rat
RGD:620017
116487
Dog
transforming growth factor beta induced
VGNC:47311
481519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta induced
Macaque
transforming growth factor beta induced
Mouse
Rat
Dog
transforming growth factor beta induced
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15582-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (91)
1 – 10 of 91
ITGA3
Tchem
Novelty: 0.00505981
Score: 0.928
Data Source: STRINGDB
HSPG2
Tbio
Family: Enzyme
Novelty: 0.00159541
Score: 0.924
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.922
Data Source: STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.921
Data Source: STRINGDB
ITGAV
Tchem
Novelty: 0.00148589
Score: 0.919
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.912
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.911
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.91
Data Source: STRINGDB
APCS
Tchem
Novelty: 0.00155111
Score: 0.904
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.851
Data Source: STRINGDB
Publication Statistics
PubMed Score  672.13

PubMed score by year
PubTator Score  502.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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