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Tbio
C4B
Complement C4-B

Protein Summary
Description
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375177
  • ENSP00000364321
  • ENSG00000228454
  • ENST00000411583
  • ENSP00000407942
  • ENSG00000228267
  • ENST00000435363
  • ENSP00000415941
  • ENSG00000224389
  • ENST00000435500
  • ENSP00000412786
  • ENSG00000233312
  • ENST00000449788
  • ENSP00000414200
  • ENSG00000236625

Symbol
  • CO4
  • CPAMD3
  • CH
  • C4F
  • CO4
  • C4B1
  • C4B2
  • C4B3
  • C4B5
  • C4BD
  • C4B12
  • C4B_2
  • CPAMD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
biological term
0.82
small molecule perturbation
0.81
cell line
0.68
disease
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1519.91   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1519.91   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
17.5
reticulocyte count
1
1
1
17.5
reticulocyte count
1
1
1
17.5
reticulocyte count
1
1
1
17.5
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
17.5
reticulocyte count
1
17.5
reticulocyte count
1
17.5
reticulocyte count
1
17.5
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (148)
Activation of C3 and C5 (R-HSA-174577)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of C3 and C5
Reactome
Complement cascade
Reactome
Immune System
Reactome
Initial triggering of complement
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Activation of C3 and C5
Complement cascade
Immune System
Initial triggering of complement
Innate Immune System
Protein-Protein Interactions (189)
1 – 10 of 189
C4A
Tbio
Novelty: 0.00062793
Score: 0.995
Data Source: Reactome,STRINGDB
CD46
Tbio
Novelty: 0.00098341
Score: 0.992
Data Source: Reactome,STRINGDB
CR1
Tbio
Novelty: 0.00157449
Score: 0.991
Data Source: Reactome,STRINGDB
MASP2
Tbio
Family: Enzyme
Novelty: 0.00466852
Score: 0.986
Data Source: Reactome,STRINGDB
C1S
Tchem
Novelty: 0.00043003
Score: 0.983
Data Source: Reactome,STRINGDB
CFB
Tchem
Novelty: 0.00102672
Score: 0.982
Data Source: STRINGDB
C4BPA
Tbio
Novelty: 0.00319944
Score: 0.977
Data Source: Reactome,STRINGDB
C1R
Tclin
Novelty: 0.00210654
Score: 0.977
Data Source: Reactome,STRINGDB
C2
Tbio
Novelty: 0.00974862
Score: 0.976
Data Source: Reactome,STRINGDB
MASP1
Tbio
Family: Enzyme
Novelty: 0.0029019
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1519.91

PubMed score by year
PubTator Score  737.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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