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Tbio
SERPINE2
Glia-derived nexin

Protein Summary
Description
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258405
  • ENSP00000258405
  • ENSG00000135919
  • ENST00000409304
  • ENSP00000386412
  • ENST00000409840
  • ENSP00000386969
  • ENST00000447280
  • ENSP00000415786

Symbol
  • PI7
  • PN1
  • GDN
  • PI7
  • PN1
  • PNI
  • PI-7
  • PN-1
  • GDNPF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological process
0.96
PubMedID
0.95
small molecule perturbation
0.92
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.6   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.6   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet-derived growth factor BB measurement
2
2
2
92.3
inflammatory biomarker measurement
1
1
0
1.3
91.6
mean platelet volume
3
2
3
86.9
body height
1
1
1
39.7
interleukin 10 measurement
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet-derived growth factor BB measurement
2
92.3
inflammatory biomarker measurement
0
1.3
91.6
mean platelet volume
3
86.9
body height
1
39.7
interleukin 10 measurement
1
4.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Dissolution of Fibrin Clot
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Dissolution of Fibrin Clot
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Protein-Protein Interactions (139)
1 – 10 of 139
PLAU
Tchem
Family: Enzyme
Novelty: 0.0005322
p_int: 0.999940035
p_ni: 0.000059965
Score: 0.986
Data Source: BioPlex,STRINGDB
KLK13
Tbio
Family: Enzyme
Novelty: 0.01963129
p_int: 0.998192293
p_ni: 0.001699715
p_wrong: 0.000107992
Score: 0.602
Data Source: BioPlex,STRINGDB
LCN6
Tbio
Novelty: 0.11406686
p_int: 0.99782487
p_ni: 0.00217513
Data Source: BioPlex
RTN1
Tbio
Novelty: 0.01828064
p_int: 0.997065554
p_ni: 0.002709739
p_wrong: 0.000224707
Score: 0.177
Data Source: BioPlex,STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
p_int: 0.994270975
p_ni: 0.005729009
p_wrong: 1.6e-8
Score: 0.256
Data Source: BioPlex,STRINGDB
NAT8B
Tbio
Family: Enzyme
p_int: 0.988226686
p_ni: 0.011719687
p_wrong: 0.000053627
Data Source: BioPlex
KCNE1
Tbio
Family: IC
Novelty: 0.0015463
p_int: 0.987583369
p_ni: 0.01240454
p_wrong: 0.000012092
Data Source: BioPlex
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.982835617
p_ni: 0.017164344
p_wrong: 3.9e-8
Score: 0.163
Data Source: BioPlex,STRINGDB
C1QTNF9B
Tdark
Novelty: 0.7643008
p_int: 0.982315566
p_ni: 0.017636276
p_wrong: 0.000048158
Data Source: BioPlex
SVOPL
Tdark
Novelty: 0.46448049
p_int: 0.957432669
p_ni: 0.04252543
p_wrong: 0.000041901
Data Source: BioPlex
Publication Statistics
PubMed Score  411.60

PubMed score by year
PubTator Score  813.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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