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Tbio
ICAM2
Intercellular adhesion molecule 2

Protein Summary
Description
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412356
  • ENSP00000415283
  • ENSG00000108622
  • ENST00000418105
  • ENSP00000388666
  • ENST00000449662
  • ENSP00000392634
  • ENST00000579687
  • ENSP00000462579
  • ENST00000579788
  • ENSP00000464665

Symbol
  • CD102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
PubMedID
0.74
protein domain
0.73
tissue sample
0.7
disease perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.54   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 788   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.54   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 788   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intercellular adhesion molecule 2
VGNC:9329
494137
Macaque
intercellular adhesion molecule 2
574158
Mouse
MGI:96394
15896
Rat
RGD:1359660
360647
Dog
intercellular adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:5345]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intercellular adhesion molecule 2
Macaque
intercellular adhesion molecule 2
Mouse
Rat
Dog
intercellular adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:5345]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13598-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
Extracellular matrix organization
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Extracellular matrix organization
Immune System
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (77)
1 – 10 of 77
ARL6IP5
Tbio
Novelty: 0.00871985
p_int: 0.996682278
p_ni: 0.003317722
Score: 0.177
Data Source: BioPlex,STRINGDB
C1QL1
Tdark
Novelty: 0.11689088
p_int: 0.987218421
p_ni: 0.012781507
p_wrong: 7.2e-8
Score: 0.209
Data Source: BioPlex,STRINGDB
RTN2
Tbio
Novelty: 0.05184418
p_int: 0.974137969
p_ni: 0.025861962
p_wrong: 6.9e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
MAD2L2
Tbio
Novelty: 0.01091072
p_int: 0.9686795
p_ni: 0.0313205
Data Source: BioPlex
NRP1
Tchem
Novelty: 0.00153628
p_int: 0.928037581
p_ni: 0.071962419
Score: 0.304
Data Source: BioPlex,STRINGDB
YIF1B
Tbio
Novelty: 0.06478298
p_int: 0.892017832
p_ni: 0.107982168
Score: 0.29
Data Source: BioPlex,STRINGDB
LGALS1
Tchem
Novelty: 0.00106509
p_int: 0.867949941
p_ni: 0.131959367
p_wrong: 0.000090692
Score: 0.179
Data Source: BioPlex,STRINGDB
CD209
Tbio
Novelty: 0.001172
Score: 0.982
Data Source: Reactome,STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.977
Data Source: STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score  172.54

PubMed score by year
PubTator Score  127.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer