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Tbio
GSDMB
Gasdermin-B

Protein Summary
Description
The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable). This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309481
  • ENSP00000312584
  • ENSG00000073605
  • ENST00000360317
  • ENSP00000353465
  • ENST00000394175
  • ENSP00000377729
  • ENST00000394179
  • ENSP00000377733
  • ENST00000418519
  • ENSP00000415049
  • ENST00000520542
  • ENSP00000430157

Symbol
  • GSDML
  • GSDML
  • PP4052
  • PRO2521
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.84
cell type or tissue
0.69
cell line
0.68
disease
0.63
tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.25   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.25   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
8
1
1.1
99.8
childhood onset asthma
3
3
0
1.3
99
6
4
4
1.1
94.5
age at onset
2
4
2
1.2
89.1
2
2
0
1.3
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
99.8
childhood onset asthma
0
1.3
99
4
1.1
94.5
age at onset
2
1.2
89.1
0
1.3
83.6
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (42)
1 – 10 of 42
ORMDL3
Tbio
Novelty: 0.00958976
Score: 0.916
Data Source: STRINGDB
ZPBP2
Tbio
Novelty: 0.06726687
Score: 0.836
Data Source: STRINGDB
GSDMC
Tbio
Novelty: 0.09848013
Score: 0.809
Data Source: STRINGDB
IKZF3
Tbio
Family: TF
Novelty: 0.01038728
Score: 0.711
Data Source: STRINGDB
IL1RL1
Tbio
Novelty: 0.00541949
Score: 0.641
Data Source: STRINGDB
PGAP3
Tbio
Novelty: 0.01842385
Score: 0.625
Data Source: STRINGDB
EAF2
Tbio
Family: TF
Novelty: 0.08392419
Score: 0.62
Data Source: STRINGDB
DENND1B
Tbio
Novelty: 0.07206972
Score: 0.587
Data Source: STRINGDB
IL18R1
Tbio
Novelty: 0.01634385
Score: 0.584
Data Source: STRINGDB
IL18
Tbio
Novelty: 0.00022844
Score: 0.579
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.25

PubMed score by year
PubTator Score  41.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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