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Tbio
NBEAL2
Neurobeachin-like protein 2

Protein Summary
Description
Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450053
  • ENSP00000415034
  • ENSG00000160796

Symbol
  • KIAA0540
  • GPS
  • BDPLT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue sample
0.61
cell line
0.59
transcription factor
0.53
small molecule perturbation
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.2   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.2   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurobeachin like 2
VGNC:2436
460329
Macaque
neurobeachin like 2
712454
Mouse
MGI:2448554
235627
Rat
RGD:1306501
316014
Horse
neurobeachin like 2
VGNC:20569
100064971
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurobeachin like 2
Macaque
neurobeachin like 2
Mouse
Rat
Horse
neurobeachin like 2
Protein Structure (0 Structures, 8 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (103)
1 – 10 of 103
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.999999873
p_ni: 2e-9
p_wrong: 1.25e-7
Data Source: BioPlex
VAMP8
Tbio
Novelty: 0.01083228
Score: 0.921
Data Source: STRINGDB
CYBA
Tbio
Novelty: 0.00177762
Score: 0.917
Data Source: STRINGDB
RAB14
Tbio
Family: Enzyme
Novelty: 0.01876172
Score: 0.914
Data Source: STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.913
Data Source: STRINGDB
ADAM8
Tchem
Family: Enzyme
Novelty: 0.00871246
Score: 0.911
Data Source: STRINGDB
PLAU
Tchem
Family: Enzyme
Novelty: 0.0005322
Score: 0.911
Data Source: STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.911
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.91
Data Source: STRINGDB
RAP2B
Tbio
Family: Enzyme
Novelty: 0.00347321
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.20

PubMed score by year
PubTator Score  213.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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