Tdark ABHD4 Protein ABHD4

Protein Summary

Description

Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).

Uniprot Accession IDs

• Q8TB40
• B4DDH7
• Q9H9E0

Gene Name

• ABHD4

Ensembl ID

• ENST00000418446
• ENSP00000388751
• ENSG00000100439
• ENST00000428304
• ENSP00000414558

Symbol

• ABH4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
small molecule perturbation	0.85
disease	0.84
disease perturbation	0.83
metabolite	0.78

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.62   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.62   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (5)

Reactome (5)

Acyl chain remodelling of PE (R-HSA-1482839)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Acyl chain remodelling of PE	29 targets	R-HSA-1482839
Reactome	Glycerophospholipid biosynthesis	129 targets	R-HSA-1483206
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Phospholipid metabolism	211 targets	R-HSA-1483257

Name	Explore in Pharos	Explore in Source
Acyl chain remodelling of PE	29 targets	R-HSA-1482839
Glycerophospholipid biosynthesis	129 targets	R-HSA-1483206
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Phospholipid metabolism	211 targets	R-HSA-1483257

Gene Ontology Terms (7)

Functions (2)

Components (2)

Processes (3)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
carboxylic ester hydrolase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
hydrolase activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (51)

Explore Interacting Targets

1 – 10 of 51

• See Interactions on String-DB

GDE1

Tbio

Family: Enzyme

Novelty: 0.11583012

Score: 0.839

Data Source: STRINGDB

NAPEPLD

Tbio

Family: Enzyme

Novelty: 0.01113091

Score: 0.82

Data Source: STRINGDB

FAAH2

Tchem

Family: Enzyme

Novelty: 0.14778758

Score: 0.743

Data Source: STRINGDB

PTPN22

Tchem

Family: Enzyme

Novelty: 0.0018748

Score: 0.716

Data Source: STRINGDB

ABHD12

Tchem

Family: Enzyme

Novelty: 0.0397

Score: 0.708

Data Source: STRINGDB

FAAH

Tchem

Family: Enzyme

Novelty: 0.00204327

Score: 0.702

Data Source: STRINGDB

ABHD6

Tchem

Family: Enzyme

Novelty: 0.02917188

Score: 0.691

Data Source: STRINGDB

METTL3

Tbio

Family: Enzyme

Novelty: 0.01066956

Score: 0.668

Data Source: STRINGDB

MGLL

Tchem

Family: Enzyme

Novelty: 0.00291863

Score: 0.657

Data Source: STRINGDB

TOX4

Tbio

Family: TF

Novelty: 0.03661513

Score: 0.618

Data Source: STRINGDB

Publication Statistics

PubMed Score  3.62

PubMed score by year

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PubTator Score  2.58

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSLPNQNKIWTVTVSPEQNDRTP

1-70

LVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEGAEDEFVTSIETWRETMGIPSM

70-140

ILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSEIRAPPAWVKAVASVLGRSNPLAVLRVA

140-210

GPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKD

210-280

VPITMIYGSDTWIDTSTGKKVKMQRPDSYVRDMEIKGASHHVYADQPHIFNAVVEEICDSVD

280-342

MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSLPNQNKIWTVTVSPEQNDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSEIRAPPAWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGSDTWIDTSTGKKVKMQRPDSYVRDMEIKGASHHVYADQPHIFNAVVEEICDSVD

Find similar targets by:

Uniprot Keyword

Alternative splicing
Complete proteome
Hydrolase
Lipid degradation
Lipid metabolism
Reference proteome