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Tbio
SS18
Protein SSXT

Protein Summary
Description
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269137
  • ENSP00000269137
  • ENSG00000141380
  • ENST00000415083
  • ENSP00000414516

Symbol
  • SSXT
  • SYT
  • SYT
  • SSXT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.91
disease perturbation
0.9
cell type or tissue
0.82
histone modification site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.6   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.6   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
68.2
basophil count
1
1
1
41.8
autoimmune thyroid disease
1
1
0
1.1
32.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
68.2
basophil count
1
41.8
autoimmune thyroid disease
0
1.1
32.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SS18, nBAF chromatin remodeling complex subunit
VGNC:10460
455345
Macaque
SS18, nBAF chromatin remodeling complex subunit
709897
Mouse
MGI:107708
268996
Rat
RGD:1311919
361295
Dog
SS18, nBAF chromatin remodeling complex subunit
VGNC:46823
480171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SS18, nBAF chromatin remodeling complex subunit
Macaque
SS18, nBAF chromatin remodeling complex subunit
Mouse
Rat
Dog
SS18, nBAF chromatin remodeling complex subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15532-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (79)
1 – 10 of 79
BRD9
Tchem
Family: Epigenetic
Novelty: 0.03450227
p_int: 0.99999973
p_ni: 1.64e-7
p_wrong: 1.05e-7
Score: 0.925
Data Source: BioPlex,STRINGDB
BICRA
Tbio
Novelty: 0.13482404
p_int: 0.999999669
p_ni: 3.28e-7
p_wrong: 3e-9
Score: 0.954
Data Source: BioPlex,STRINGDB
ARID1B
Tbio
Family: TF
Novelty: 0.00731933
p_int: 0.999999372
p_ni: 6.21e-7
p_wrong: 7e-9
Score: 0.949
Data Source: BioPlex,STRINGDB
SMARCA2
Tchem
Family: Epigenetic
Novelty: 0.00231554
p_int: 0.999999282
p_ni: 7.18e-7
Score: 0.946
Data Source: BioPlex,STRINGDB
SMARCD3
Tbio
Novelty: 0.03423481
p_int: 0.999998135
p_ni: 0.000001865
Score: 0.929
Data Source: BioPlex,STRINGDB
DPF1
Tbio
Family: Epigenetic
Novelty: 0.0713809
p_int: 0.999997833
p_ni: 0.00000206
p_wrong: 1.07e-7
Score: 0.935
Data Source: BioPlex,STRINGDB
SMARCD2
Tbio
Novelty: 0.04006597
p_int: 0.999997654
p_ni: 0.000002346
Score: 0.953
Data Source: BioPlex,STRINGDB
DPF3
Tbio
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999995742
p_ni: 0.000004258
Score: 0.94
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.999973321
p_ni: 0.000026679
Score: 0.951
Data Source: BioPlex,STRINGDB
SMARCD1
Tbio
Novelty: 0.03176642
p_int: 0.999960331
p_ni: 0.000039669
Score: 0.941
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  128.60

PubMed score by year
PubTator Score  67.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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