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Tclin
PSMA1
Proteasome subunit alpha type-1

Protein Summary
Description
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396394
  • ENSP00000379676
  • ENSG00000129084
  • ENST00000418988
  • ENSP00000414359

Symbol
  • HC2
  • NU
  • PROS30
  • PSC2
  • NU
  • HC2
  • PROS30
  • HEL-S-275
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
biological process
0.98
interacting protein
0.96
co-expressed gene
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.87   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.87   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bortezomib
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
2
2
99.6
triglyceride measurement
2
1
2
42.6
high density lipoprotein cholesterol measurement
1
1
1
28.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
99.6
triglyceride measurement
2
42.6
high density lipoprotein cholesterol measurement
1
28.2
Protein Data Bank (31)
1 – 5 of 31
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (155)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (465)
1 – 10 of 465
PSMG4
Tdark
Novelty: 0.05339077
p_int: 0.999999437
p_ni: 5.63e-7
Score: 0.707
Data Source: BioPlex,STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
p_int: 0.999998759
p_ni: 0.000001241
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB7
Tbio
Family: Enzyme
Novelty: 0.06547657
p_int: 0.999998567
p_ni: 0.000001433
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB3
Tbio
Family: Enzyme
Novelty: 0.12791198
p_int: 0.999997017
p_ni: 0.000002983
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMG2
Tbio
Novelty: 0.11082503
p_int: 0.999996609
p_ni: 0.000003391
Score: 0.994
Data Source: BioPlex,STRINGDB
PSME4
Tbio
Novelty: 0.01206213
p_int: 0.999984771
p_ni: 0.000015229
Score: 0.997
Data Source: BioPlex,STRINGDB
PSMG3
Tchem
Novelty: 0.01730294
p_int: 0.999972196
p_ni: 0.000027804
Score: 0.708
Data Source: BioPlex,STRINGDB
PSMB1
Tclin
Family: Enzyme
Novelty: 0.0255917
p_int: 0.999936429
p_ni: 0.000063571
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB9
Tchem
Family: Enzyme
Novelty: 0.0016249
p_int: 0.999934534
p_ni: 0.000065466
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.06714761
p_int: 0.999901171
p_ni: 0.000098829
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  67.87

PubMed score by year
PubTator Score  16.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer