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Tbio
TOM1
Target of Myb protein 1

Protein Summary
Description
May be involved in intracellular trafficking. Probable association with membranes. This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000411850
  • ENSP00000413697
  • ENSG00000100284
  • ENST00000425375
  • ENSP00000394924
  • ENST00000447733
  • ENSP00000398876
  • ENST00000449058
  • ENSP00000394466
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.83
ligand (protein) perturbation
0.83
hub protein
0.79
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.38   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.38   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
48.1
1
1
0
1.2
34.7
total cholesterol measurement
2
1
2
21.9
low density lipoprotein cholesterol measurement
1
1
1
16.4
1
1
0
1.1
11.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
48.1
0
1.2
34.7
total cholesterol measurement
2
21.9
low density lipoprotein cholesterol measurement
1
16.4
0
1.1
11.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
target of myb1 membrane trafficking protein
VGNC:5997
739845
Macaque
target of myb1 membrane trafficking protein
717499
Mouse
MGI:1338026
21968
Rat
RGD:1308024
361370
Dog
target of myb1 membrane trafficking protein
VGNC:47707
608746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
target of myb1 membrane trafficking protein
Macaque
target of myb1 membrane trafficking protein
Mouse
Rat
Dog
target of myb1 membrane trafficking protein
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60784-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (187)
1 – 10 of 187
MAP3K1
Tchem
Family: Kinase
Novelty: 0.0041131
p_int: 0.999999707
p_ni: 9.4e-8
p_wrong: 1.99e-7
Data Source: BioPlex
ZFYVE16
Tbio
Novelty: 0.10765234
p_int: 0.999997787
p_ni: 0.000002211
p_wrong: 1e-9
Score: 0.854
Data Source: BioPlex,STRINGDB
SNX5
Tbio
Novelty: 0.04075649
p_int: 0.985183597
p_ni: 0.014816403
Data Source: BioPlex
CRMP1
Tbio
Family: Enzyme
Novelty: 0.01998451
p_int: 0.969747931
p_ni: 0.030252066
p_wrong: 3e-9
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.935587816
p_ni: 0.064412184
Data Source: BioPlex
TOLLIP
Tbio
Novelty: 0.01032371
p_int: 0.931620828
p_ni: 0.068379172
Score: 0.928
Data Source: BioPlex,STRINGDB
CUEDC1
Tbio
Novelty: 0.14401061
p_int: 0.922200671
p_ni: 0.077799329
Score: 0.554
Data Source: BioPlex,STRINGDB
CHAC2
Tbio
Family: Enzyme
Novelty: 0.14706039
p_int: 0.860178272
p_ni: 0.139821082
p_wrong: 6.46e-7
Data Source: BioPlex
SNX2
Tbio
Novelty: 0.03880384
p_int: 0.758720589
p_ni: 0.241279336
p_wrong: 7.6e-8
Data Source: BioPlex
HMOX2
Tchem
Family: Enzyme
Novelty: 0.00180703
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  133.38

PubMed score by year
PubTator Score  37.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer