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Tdark
AGBL1
Cytosolic carboxypeptidase 4

Protein Summary
Description
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000635782
  • ENSP00000490428
  • ENSG00000273540

Symbol
  • CCP4
  • CCP4
  • FECD8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
cell line
0.88
molecular function
0.67
interacting protein
0.63
disease
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.1   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.1   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
2
3
84
neuroticism measurement
2
1
1
5.5
40.8
bitter alcoholic beverage consumption measurement
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
84
neuroticism measurement
1
5.5
40.8
bitter alcoholic beverage consumption measurement
1
8.3
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (18)
1 – 10 of 18
LOXHD1
Tbio
Family: Enzyme
Novelty: 0.06557997
Score: 0.799
Data Source: STRINGDB
SLC4A11
Tbio
Family: Transporter
Novelty: 0.00938427
Score: 0.659
Data Source: STRINGDB
DNAJC7
Tbio
Novelty: 0.02133191
Score: 0.657
Data Source: STRINGDB
TTC1
Tbio
Novelty: 0.01389711
Score: 0.603
Data Source: STRINGDB
PHF12
Tbio
Family: Epigenetic
Novelty: 0.00240295
Score: 0.593
Data Source: STRINGDB
COL8A2
Tbio
Novelty: 0.01672103
Score: 0.563
Data Source: STRINGDB
OXT
Tbio
Novelty: 0.00005116
Score: 0.547
Data Source: STRINGDB
KANK4
Tdark
Novelty: 0.22871735
Score: 0.511
Data Source: STRINGDB
EFCAB11
Tdark
Novelty: 0.68998855
Score: 0.504
Data Source: STRINGDB
ZNF398
Tbio
Family: TF
Novelty: 0.01578856
Score: 0.484
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.10

PubMed score by year
PubTator Score  56.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer