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Tclin
SCN5A
Sodium channel protein type 5 subunit alpha

Protein Classes
Protein Summary
Description
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555). It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (PubMed:19074138). The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333535
  • ENSP00000328968
  • ENSG00000183873
  • ENST00000423572
  • ENSP00000398266

Symbol
  • HB1
  • HB2
  • HH1
  • IVF
  • VF1
  • HBBD
  • ICCD
  • LQT3
  • SSS1
  • CDCD2
  • CMD1E
  • CMPD2
  • PFHB1
  • Nav1.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
drug
0.95
protein domain
0.92
biological process
0.84
biological term
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2061.21   (req: < 5)
Gene RIFs: 459   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2061.21   (req: >= 5)
Gene RIFs: 459   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 391
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 33
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
5
7
0
3
99.2
QT interval
4
4
2
1.6
96.1
electrocardiography
2
5
120
94.5
QRS duration
1
1
1
88
Brugada syndrome
1
1
0
1.7
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
0
3
99.2
QT interval
2
1.6
96.1
electrocardiography
120
94.5
QRS duration
1
88
Brugada syndrome
0
1.7
86.6
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Gene Ontology Terms (68)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (201)
1 – 10 of 201
FGF12
Tbio
Novelty: 0.02094849
p_int: 0.999987629
p_ni: 0.00000231
p_wrong: 0.000010061
Score: 0.918
Data Source: BioPlex,STRINGDB
SCN1B
Tbio
Family: IC
Novelty: 0.00910273
Score: 0.987
Data Source: Reactome,STRINGDB
ANK3
Tbio
Novelty: 0.00429246
Score: 0.984
Data Source: STRINGDB
SCN2B
Tbio
Family: IC
Novelty: 0.03773629
Score: 0.982
Data Source: STRINGDB
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
Score: 0.982
Data Source: STRINGDB
SCN4B
Tbio
Family: IC
Novelty: 0.02505113
Score: 0.977
Data Source: STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.975
Data Source: Reactome,STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.959
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.958
Data Source: STRINGDB
NFASC
Tbio
Novelty: 0.00545331
Score: 0.951
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  2061.21

PubMed score by year
PubTator Score  1227.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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