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Tbio
USP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

Protein Summary
Description
Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274030
  • ENSP00000274030
  • ENSG00000145390
  • ENST00000450251
  • ENSP00000409906

Symbol
  • KIAA1350
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor binding site profile
0.71
virus perturbation
0.68
cell type or tissue
0.67
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.59   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.59   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
51.9
body mass index
1
1
1
23.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
51.9
body mass index
1
23.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 53
VGNC:712
461457
Macaque
ubiquitin specific peptidase 53
705228
Mouse
MGI:2139607
99526
Rat
RGD:1306615
295425
Dog
ubiquitin specific peptidase 53
VGNC:48202
487923
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 53
Macaque
ubiquitin specific peptidase 53
Mouse
Rat
Dog
ubiquitin specific peptidase 53
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (29)
1 – 10 of 29
FAM168A
Tbio
Novelty: 0.08308907
Score: 0.75
Data Source: STRINGDB
DDB2
Tbio
Novelty: 0.00648809
Score: 0.662
Data Source: STRINGDB
MPHOSPH9
Tbio
Family: Enzyme
Novelty: 0.06682688
Score: 0.643
Data Source: STRINGDB
ACER2
Tchem
Family: Enzyme
Novelty: 0.040885
Score: 0.621
Data Source: STRINGDB
ACER1
Tbio
Family: Enzyme
Novelty: 0.05571844
Score: 0.62
Data Source: STRINGDB
ACER3
Tbio
Family: Enzyme
Novelty: 0.01058501
Score: 0.587
Data Source: STRINGDB
XAF1
Tbio
Novelty: 0.01458015
Score: 0.555
Data Source: STRINGDB
ALG13
Tbio
Family: Enzyme
Novelty: 0.04054611
Score: 0.546
Data Source: STRINGDB
ODAM
Tbio
Novelty: 0.01922413
Score: 0.52
Data Source: STRINGDB
DAPK2
Tchem
Family: Kinase
Novelty: 0.02391861
Score: 0.52
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.59

PubMed score by year
PubTator Score  0.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer