Protein Classes
Protein Summary
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
- ENST00000340958
- ENSP00000342445
- ENSG00000189143
- ENST00000431918
- ENSP00000388639
- ENST00000435050
- ENSP00000409544
- CPER
- CPETR1
- WBSCR8
- CPER
- CPE-R
- CPETR
- CPETR1
- WBSCR8
- hCPE-R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.96 | ||
transcription factor binding site profile | 0.69 | ||
disease perturbation | 0.68 | ||
disease | 0.67 | ||
chemical | 0.62 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 401.7 (req: < 5)
Gene RIFs: 118 (req: <= 3)
Antibodies: 532 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 401.7 (req: >= 5)
Gene RIFs: 118 (req: > 3)
Antibodies: 532 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (118)
Reactome (4)
KEGG (4)
WikiPathways (110)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Tight junction interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Tight junction interactions | ||||
Gene Ontology Terms (18)
Functions (4)
Components (8)
Processes (6)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (126)
1 – 10 of 126
CLDN12
Novelty: 0.06470623
Score: 0.979
Data Source: STRINGDB
OCLN
Novelty: 0.00062788
Score: 0.947
Data Source: STRINGDB
CLDN7
Novelty: 0.00860191
Score: 0.937
Data Source: STRINGDB
CLDN3
Novelty: 0.00374279
Score: 0.933
Data Source: STRINGDB
CLDN23
Novelty: 0.16372511
Score: 0.93
Data Source: STRINGDB
CLDN16
Novelty: 0.0103486
Score: 0.919
Data Source: STRINGDB
CLDN11
Novelty: 0.00250727
Score: 0.915
Data Source: STRINGDB
CLDN8
Novelty: 0.03010422
Score: 0.912
Data Source: STRINGDB
CLDN18
Novelty: 0.01754685
Score: 0.911
Data Source: STRINGDB
CLDN1
Novelty: 0.00729249
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score 401.70
PubMed score by year
PubTator Score 333
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSL
1-70
LALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTA
70-140
HNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV
140-209
MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV
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