Tbio CLDN4 Claudin-4

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Claudin-4

Protein Summary

Description

Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• O14493

Gene Name

• CLDN4

Ensembl ID

• ENST00000340958
• ENSP00000342445
• ENSG00000189143
• ENST00000431918
• ENSP00000388639
• ENST00000435050
• ENSP00000409544

Symbol

• CPER
• CPETR1
• WBSCR8
• CPER
• CPE-R
• CPETR
• CPETR1
• WBSCR8
• hCPE-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.96
transcription factor binding site profile	0.69
disease perturbation	0.68
disease	0.67
chemical	0.62

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.7   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 532   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.7   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 532   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (118)

Reactome (4)

KEGG (4)

WikiPathways (110)

Cell junction organization (R-HSA-446728)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Tight junction interactions	30 targets	R-HSA-420029

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Tight junction interactions	30 targets	R-HSA-420029

Gene Ontology Terms (18)

Functions (4)

Components (8)

Processes (6)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
chloride channel activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
identical protein binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
transmembrane signaling receptor activity	Traceable Author Statement (TAS)	ProtInc
structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (126)

Explore Interacting Targets

1 – 10 of 126

• See Interactions on String-DB

CLDN12

Tbio

Novelty: 0.06470623

Score: 0.979

Data Source: STRINGDB

OCLN

Tbio

Novelty: 0.00062788

Score: 0.947

Data Source: STRINGDB

CLDN7

Tbio

Novelty: 0.00860191

Score: 0.937

Data Source: STRINGDB

CLDN3

Tbio

Novelty: 0.00374279

Score: 0.933

Data Source: STRINGDB

CLDN23

Tbio

Novelty: 0.16372511

Score: 0.93

Data Source: STRINGDB

CLDN16

Tbio

Novelty: 0.0103486

Score: 0.919

Data Source: STRINGDB

CLDN11

Tbio

Novelty: 0.00250727

Score: 0.915

Data Source: STRINGDB

CLDN8

Tbio

Novelty: 0.03010422

Score: 0.912

Data Source: STRINGDB

CLDN18

Tbio

Novelty: 0.01754685

Score: 0.911

Data Source: STRINGDB

CLDN1

Tbio

Novelty: 0.00729249

Score: 0.911

Data Source: STRINGDB

Publication Statistics

PubMed Score  401.70

PubMed score by year

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PubTator Score  333

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSL

1-70

LALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTA

70-140

HNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV

140-209

MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV

Find similar targets by:

Uniprot Keyword

3D-structure
Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disulfide bond
Ion channel
Ion transport
Membrane