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Tchem
FBP1
Fructose-1,6-bisphosphatase 1

Protein Summary
Description
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375326
  • ENSP00000364475
  • ENSG00000165140
  • ENST00000415431
  • ENSP00000408025

Symbol
  • FBP
  • FBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
molecular function
0.96
gene perturbation
0.85
transcription factor perturbation
0.8
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.81   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.81   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 240
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (132)
1 – 10 of 132
FBP2
Tbio
Family: Enzyme
Novelty: 0.00744179
p_int: 1
Score: 0.906
Data Source: BioPlex,STRINGDB
ST6GALNAC5
Tbio
Family: Enzyme
Novelty: 0.03537127
p_int: 0.999998849
p_ni: 0.000001145
p_wrong: 6e-9
Score: 0.516
Data Source: BioPlex,STRINGDB
CCDC68
Tbio
Novelty: 0.18545776
p_int: 0.996340889
p_ni: 0.003647294
p_wrong: 0.000011817
Score: 0.226
Data Source: BioPlex,STRINGDB
SLAMF8
Tbio
Novelty: 0.2205719
p_int: 0.982810996
p_ni: 0.017188961
p_wrong: 4.2e-8
Score: 0.557
Data Source: BioPlex,STRINGDB
TIGD7
Tdark
Novelty: 1.37837838
p_int: 0.977344327
p_ni: 0.022588385
p_wrong: 0.000067288
Score: 0.359
Data Source: BioPlex,STRINGDB
CROT
Tbio
Family: Enzyme
Novelty: 0.04628118
p_int: 0.969960459
p_ni: 0.030036216
p_wrong: 0.000003325
Score: 0.228
Data Source: BioPlex,STRINGDB
SAMD7
Tdark
Novelty: 0.60301508
p_int: 0.954356049
p_ni: 0.045643951
Score: 0.19
Data Source: BioPlex,STRINGDB
GIMAP2
Tbio
Family: Enzyme
Novelty: 0.11565672
p_int: 0.877370699
p_ni: 0.122629299
p_wrong: 2e-9
Score: 0.203
Data Source: BioPlex,STRINGDB
TALDO1
Tbio
Family: Enzyme
Novelty: 0.00254889
Score: 0.973
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00073017
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  172.81

PubMed score by year
PubTator Score  132.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQ
1-70
VKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIY
70-140
RKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIY
140-210
SLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLY
210-280
ECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
280-338
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ