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Tbio
PBX1
Pre-B-cell leukemia transcription factor 1

Protein Summary
Description
Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity). This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367897
  • ENSP00000356872
  • ENSG00000185630
  • ENST00000420696
  • ENSP00000405890
  • ENST00000627490
  • ENSP00000485692

Symbol
  • PRL
  • CAKUHED
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
PubMedID
0.95
virus perturbation
0.92
biological process
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.42   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.42   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
74.3
balding measurement
1
1
1
73.7
BMI-adjusted waist-hip ratio
1
1
1
73
HIV-1 infection
1
1
1
66.9
viral load
1
1
1
66.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
74.3
balding measurement
1
73.7
BMI-adjusted waist-hip ratio
1
73
HIV-1 infection
1
66.9
viral load
1
66.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PBX homeobox 1
VGNC:11604
457474
Macaque
PBX homeobox 1
694416
Mouse
MGI:97495
18514
Rat
RGD:1308213
304947
Dog
PBX homeobox 1
VGNC:44286
488669
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PBX homeobox 1
Macaque
PBX homeobox 1
Mouse
Rat
Dog
PBX homeobox 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P40424-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Reactome
NOTCH3 Intracellular Domain Regulates Transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
NOTCH3 Intracellular Domain Regulates Transcription
Signal Transduction
Gene Ontology Terms (29)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (240)
1 – 10 of 240
PKNOX1
Tbio
Family: TF
Novelty: 0.01063674
p_int: 0.999999845
p_ni: 1.55e-7
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
MEIS2
Tbio
Family: TF
Novelty: 0.01393828
p_int: 0.999999486
p_ni: 5.14e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
MAB21L1
Tbio
Novelty: 0.07438538
p_int: 0.999896542
p_ni: 0.000103458
Score: 0.85
Data Source: BioPlex,STRINGDB
FAM222A
Tdark
Novelty: 0.41466126
p_int: 0.999040769
p_ni: 0.000959231
Score: 0.828
Data Source: BioPlex,STRINGDB
LMX1B
Tbio
Family: TF
Novelty: 0.00405645
p_int: 0.998790429
p_ni: 0.001209563
p_wrong: 8e-9
Score: 0.822
Data Source: BioPlex,STRINGDB
MAB21L2
Tbio
Novelty: 0.05770595
p_int: 0.998558768
p_ni: 0.001441232
Score: 0.702
Data Source: BioPlex,STRINGDB
VWA5A
Tbio
Novelty: 0.0802354
p_int: 0.99806611
p_ni: 0.00193389
Score: 0.275
Data Source: BioPlex,STRINGDB
C5orf24
Tdark
Novelty: 3.95177775
p_int: 0.993276965
p_ni: 0.006723035
Score: 0.373
Data Source: BioPlex,STRINGDB
CCDC120
Tbio
Novelty: 0.48574876
p_int: 0.992458394
p_ni: 0.007541604
p_wrong: 1e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
MAGEA1
Tbio
Novelty: 0.00506874
p_int: 0.986460901
p_ni: 0.013539099
Data Source: BioPlex
Publication Statistics
PubMed Score  295.42

PubMed score by year
PubTator Score  169.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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