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Tbio
ILF3
Interleukin enhancer-binding factor 3

Protein Summary
Description
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250241
  • ENSP00000250241
  • ENSG00000129351
  • ENST00000407004
  • ENSP00000384660
  • ENST00000449870
  • ENSP00000404121
  • ENST00000588657
  • ENSP00000468181
  • ENST00000589998
  • ENSP00000465219
  • ENST00000590261
  • ENSP00000468156
  • ENST00000592763
  • ENSP00000465515

Symbol
  • DRBF
  • MPHOSPH4
  • NF90
  • CBTF
  • DRBF
  • MMP4
  • MPP4
  • NF90
  • NFAR
  • NF110
  • NF90a
  • NF90b
  • NF90c
  • NFAR2
  • TCP80
  • DRBP76
  • NF110b
  • NFAR-1
  • NFAR-2
  • NFAR90
  • TCP110
  • MPP4110
  • NF90ctv
  • NFAR110
  • MPHOSPH4
  • NF-AT-90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
transcription factor perturbation
0.99
hub protein
0.96
transcription factor binding site profile
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.33   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.33   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
80.3
lifestyle measurement
1
1
1
65
1
1
1
28.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
80.3
lifestyle measurement
1
65
1
28.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (257)
1 – 10 of 257
ILF2
Tbio
Novelty: 0.01598188
p_int: 0.999863232
p_ni: 0.000136768
Score: 0.992
Data Source: BioPlex,STRINGDB
HNRNPL
Tbio
Novelty: 0.01048413
Score: 0.984
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.983
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.977
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.974
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.973
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00110045
Score: 0.972
Data Source: STRINGDB
XPO5
Tbio
Novelty: 0.0040002
Score: 0.971
Data Source: STRINGDB
PTBP1
Tbio
Novelty: 0.00184728
Score: 0.97
Data Source: STRINGDB
HNRNPK
Tbio
Novelty: 0.00354731
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  251.33

PubMed score by year
PubTator Score  136.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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