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Tbio
TANGO2
Transport and Golgi organization protein 2 homolog

Protein Summary
Description
This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327374
  • ENSP00000332721
  • ENSG00000183597
  • ENST00000398042
  • ENSP00000381122
  • ENST00000401833
  • ENSP00000384827
  • ENST00000401886
  • ENSP00000385662
  • ENST00000432883
  • ENSP00000402926
  • ENST00000434570
  • ENSP00000391262
  • ENST00000456048
  • ENSP00000403645

Symbol
  • C22orf25
  • MECRCN
  • C22orf25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
transcription factor perturbation
0.68
cell line
0.62
cell type or tissue
0.58
disease
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.51   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.51   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
29.4
intraocular pressure measurement
1
1
1
26.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
29.4
intraocular pressure measurement
1
26.8
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (42)
1 – 10 of 42
SH3GL2
Tbio
Novelty: 0.0188955
p_int: 0.999626055
p_ni: 0.000373941
p_wrong: 4e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
PRDX1
Tbio
Novelty: 0.00207935
Score: 0.818
Data Source: STRINGDB
MRPL40
Tbio
Novelty: 0.09916967
Score: 0.785
Data Source: STRINGDB
TRMT2A
Tbio
Family: Enzyme
Novelty: 0.15277091
Score: 0.715
Data Source: STRINGDB
UFD1
Tbio
Novelty: 0.01230296
Score: 0.663
Data Source: STRINGDB
EMC1
Tbio
Novelty: 0.05360812
Score: 0.648
Data Source: STRINGDB
NUS1
Tbio
Family: Enzyme
Novelty: 0.02022029
Score: 0.646
Data Source: STRINGDB
ZDHHC8
Tbio
Family: Enzyme
Novelty: 0.03434357
Score: 0.625
Data Source: STRINGDB
KATNB1
Tbio
Novelty: 0.08472625
Score: 0.607
Data Source: STRINGDB
DGCR2
Tbio
Novelty: 0.05838132
Score: 0.577
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.51

PubMed score by year
PubTator Score  3.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer