You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FBXO43
F-box only protein 43

Protein Summary
Description
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428847
  • ENSP00000403293
  • ENSG00000156509

Symbol
  • EMI2
  • EMI2
  • ERP1
  • FBX43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.72
tissue sample
0.7
cell type or tissue
0.59
microRNA
0.53
gene perturbation
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.38   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.38   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 43
VGNC:867
464313
Mouse
MGI:1926053
78803
Rat
RGD:1310225
315034
Dog
F-box protein 43
VGNC:40783
481982
Horse
F-box protein 43
VGNC:17956
100055861
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 43
Mouse
Rat
Dog
F-box protein 43
Horse
F-box protein 43
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q4G163-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (67)
1 – 10 of 67
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.983
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00197887
Score: 0.974
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.96
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.919
Data Source: STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
Score: 0.911
Data Source: STRINGDB
BTRC
Tbio
Novelty: 0.00293475
Score: 0.893
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.887
Data Source: STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.886
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.837
Data Source: STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
Score: 0.834
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.38

PubMed score by year
PubTator Score  20.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer