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Tdark
TMEM177
Transmembrane protein 177

Protein Summary
Description
Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272521
  • ENSP00000272521
  • ENSG00000144120
  • ENST00000401466
  • ENSP00000385966
  • ENST00000424086
  • ENSP00000402661
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
histone modification site profile
0.82
tissue sample
0.59
transcription factor binding site profile
0.58
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
92.6
Protein-Protein Interactions (47)
1 – 10 of 47
CPVL
Tbio
Family: Enzyme
Novelty: 0.0616903
p_int: 0.796971461
p_ni: 0.196472483
p_wrong: 0.006556056
Score: 0.622
Data Source: BioPlex,STRINGDB
MRPL45
Tdark
Novelty: 0.42464896
Score: 0.824
Data Source: STRINGDB
MRPL19
Tbio
Novelty: 0.04235101
Score: 0.821
Data Source: STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
Score: 0.821
Data Source: STRINGDB
MRPL38
Tdark
Novelty: 0.71587283
Score: 0.819
Data Source: STRINGDB
MRPL24
Tdark
Novelty: 0.61597737
Score: 0.806
Data Source: STRINGDB
TSR1
Tbio
Novelty: 0.01639069
Score: 0.804
Data Source: STRINGDB
MRPL11
Tbio
Novelty: 0.1320634
Score: 0.804
Data Source: STRINGDB
GADD45GIP1
Tbio
Novelty: 0.03765684
Score: 0.802
Data Source: STRINGDB
MRPL51
Tdark
Novelty: 0.24304433
Score: 0.794
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.54

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer