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Tbio
ZNF469
Zinc finger protein 469

Protein Summary
Description
May be involved in transcriptional regulation. This gene encodes a zinc-finger protein. Low-percent homology to certain collagens suggests that it may function as a transcription factor or extra-nuclear regulator factor for the synthesis or organization of collagen fibers. Mutations in this gene cause brittle cornea syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000437464
  • ENSP00000402343
  • ENSG00000225614

Symbol
  • KIAA1858
  • BCS
  • BCS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
cell type or tissue
0.62
cell line
0.59
microRNA
0.53
phenotype
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.54   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.54   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
2
3
80.1
heel bone mineral density
2
1
2
77
appendicular lean mass
1
1
1
61.7
sex hormone-binding globulin measurement
2
1
2
42.6
basophil percentage of leukocytes
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
80.1
heel bone mineral density
2
77
appendicular lean mass
1
61.7
sex hormone-binding globulin measurement
2
42.6
basophil percentage of leukocytes
1
4.9
Protein-Protein Interactions (56)
1 – 10 of 56
CHST14
Tbio
Family: Enzyme
Novelty: 0.026494
Score: 0.775
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.726
Data Source: STRINGDB
COL8A2
Tbio
Novelty: 0.01672103
Score: 0.707
Data Source: STRINGDB
VSX1
Tbio
Family: TF
Novelty: 0.01213324
Score: 0.68
Data Source: STRINGDB
FNDC3B
Tbio
Novelty: 0.03060075
Score: 0.672
Data Source: STRINGDB
BANP
Tbio
Novelty: 0.02145545
Score: 0.655
Data Source: STRINGDB
CCDC83
Tdark
Novelty: 0.2258549
Score: 0.647
Data Source: STRINGDB
RAB3GAP1
Tbio
Family: Enzyme
Novelty: 0.0286836
Score: 0.636
Data Source: STRINGDB
LCN12
Tdark
Novelty: 0.31492521
Score: 0.631
Data Source: STRINGDB
TMEM248
Tdark
Novelty: 2.69323589
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.54

PubMed score by year
PubTator Score  22.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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