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Tbio
SEPT4
Septin-4

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317256
  • ENSP00000321071
  • ENSG00000108387
  • ENST00000317268
  • ENSP00000321674
  • ENST00000393086
  • ENSP00000376801
  • ENST00000412945
  • ENSP00000414779
  • ENST00000426861
  • ENSP00000402348
  • ENST00000457347
  • ENSP00000402000
  • ENST00000583114
  • ENSP00000463768

Symbol
  • ARTS
  • PNUTL2
  • SEP4
  • H5
  • ARTS
  • MART
  • SEP4
  • CE5B3
  • PNUTL2
  • hucep-7
  • BRADEION
  • C17orf47
  • hCDCREL-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor perturbation
0.74
cellular component
0.71
disease perturbation
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.77   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.77   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
6.4
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
6.4
77.7
Pathways (17)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Intrinsic Pathway for Apoptosis
Reactome
Programmed Cell Death
Reactome
Release of apoptotic factors from the mitochondria
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic factor-mediated response
Intrinsic Pathway for Apoptosis
Programmed Cell Death
Release of apoptotic factors from the mitochondria
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (59)
1 – 10 of 59
SEPT1
Tdark
Novelty: 0.04450119
p_int: 0.999999997
p_wrong: 3e-9
Score: 0.86
Data Source: BioPlex,STRINGDB
SEPT7
Tbio
Novelty: 0.00554708
p_int: 0.999996793
p_ni: 0.000003201
p_wrong: 6e-9
Score: 0.983
Data Source: BioPlex,STRINGDB
SEPT6
Tbio
Novelty: 0.00885503
p_int: 0.999992139
p_ni: 0.000007861
Score: 0.995
Data Source: BioPlex,STRINGDB
SEPT12
Tbio
Novelty: 0.06228277
p_int: 0.999988679
p_ni: 0.000011321
Score: 0.992
Data Source: BioPlex,STRINGDB
SEPT3
Tbio
Novelty: 0.008513
p_int: 0.999941331
p_ni: 0.000058574
p_wrong: 9.4e-8
Score: 0.94
Data Source: BioPlex,STRINGDB
SEPT2
Tbio
Novelty: 0.01047916
p_int: 0.99858189
p_ni: 0.001418052
p_wrong: 5.7e-8
Score: 0.985
Data Source: BioPlex,STRINGDB
CDC42EP4
Tdark
Novelty: 0.27965905
p_int: 0.995187539
p_ni: 0.000621217
p_wrong: 0.004191244
Score: 0.886
Data Source: BioPlex,STRINGDB
SEPT10
Tbio
Novelty: 0.14834834
p_int: 0.892558711
p_ni: 0.002728387
p_wrong: 0.104712902
Score: 0.929
Data Source: BioPlex,STRINGDB
XIAP
Tchem
Family: Enzyme
Novelty: 0.00062268
Score: 0.94
Data Source: Reactome,STRINGDB
BIRC3
Tchem
Novelty: 0.00189613
Score: 0.888
Data Source: STRINGDB
Publication Statistics
PubMed Score  263.77

PubMed score by year
PubTator Score  729.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer