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Tbio
P4HA3
Prolyl 4-hydroxylase subunit alpha-3

Protein Summary
Description
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331597
  • ENSP00000332170
  • ENSG00000149380
  • ENST00000427714
  • ENSP00000401749
  • ENST00000524388
  • ENSP00000433860
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cell type or tissue
0.79
histone modification site profile
0.71
gene perturbation
0.68
cell line
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.75   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (144)
1 – 10 of 144
ZBTB7B
Tbio
Family: TF
Novelty: 0.01942129
p_int: 1
Score: 0.255
Data Source: BioPlex,STRINGDB
KIF21A
Tbio
Novelty: 0.01535562
p_int: 0.999999995
p_ni: 5e-9
Score: 0.259
Data Source: BioPlex,STRINGDB
ZMYND8
Tbio
Family: Epigenetic
Novelty: 0.05352096
p_int: 0.999999958
p_ni: 4.2e-8
Score: 0.182
Data Source: BioPlex,STRINGDB
KMT2B
Tbio
Family: Epigenetic
Novelty: 0.00593529
p_int: 0.999999884
p_ni: 1.16e-7
Score: 0.196
Data Source: BioPlex,STRINGDB
ZNF687
Tbio
Family: TF
Novelty: 0.14707532
p_int: 0.999999514
p_ni: 4.86e-7
Data Source: BioPlex
AGAP1
Tbio
Family: Enzyme
Novelty: 0.06776705
p_int: 0.999998336
p_ni: 0.000001658
p_wrong: 7e-9
Data Source: BioPlex
SATB1
Tbio
Family: TF
Novelty: 0.00434577
p_int: 0.999996194
p_ni: 0.000003802
p_wrong: 4e-9
Data Source: BioPlex
PWWP2A
Tdark
Novelty: 0.1712947
p_int: 0.999992404
p_ni: 0.000007562
p_wrong: 3.4e-8
Data Source: BioPlex
SLBP
Tbio
Novelty: 0.00685735
p_int: 0.999992292
p_ni: 0.000004018
p_wrong: 0.000003691
Score: 0.177
Data Source: BioPlex,STRINGDB
FAM120C
Tbio
Novelty: 0.03333181
p_int: 0.999989761
p_ni: 0.000010236
p_wrong: 3e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  25.75

PubMed score by year
PubTator Score  1.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer