You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STRC
Stereocilin

Protein Summary
Description
Essential to the formation of horizontal top connectors between outer hair cell stereocilia. This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450892
  • ENSP00000401513
  • ENSG00000242866

Symbol
  • DFNB16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
cell line
0.63
tissue sample
0.61
tissue
0.58
cellular component
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.99   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.99   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
57.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
57.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stereocilin
100608534
Macaque
stereocilin
677720
Mouse
MGI:2153816
140476
Dog
stereocilin
478278
Horse
stereocilin
VGNC:51428
100056242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stereocilin
Macaque
stereocilin
Mouse
Dog
stereocilin
Horse
stereocilin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7RTU9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
CATSPER2
Tchem
Family: IC
Novelty: 0.03701031
Score: 0.962
Data Source: STRINGDB
CKMT1A
Tbio
Family: Kinase
Novelty: 0.00844533
Score: 0.809
Data Source: STRINGDB
PPIP5K1
Tbio
Family: Enzyme
Novelty: 0.01175655
Score: 0.801
Data Source: STRINGDB
HTN3
Tbio
Novelty: 0.00825966
Score: 0.741
Data Source: STRINGDB
CDAN1
Tbio
Novelty: 0.00610604
Score: 0.718
Data Source: STRINGDB
TECTB
Tbio
Novelty: 0.04489491
Score: 0.708
Data Source: STRINGDB
MYO15A
Tbio
Novelty: 0.0148787
Score: 0.693
Data Source: STRINGDB
TMC1
Tbio
Family: IC
Novelty: 0.00609628
Score: 0.684
Data Source: STRINGDB
OTOG
Tdark
Novelty: 0.04344519
Score: 0.68
Data Source: STRINGDB
PCDH15
Tbio
Novelty: 0.0097699
Score: 0.677
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.99

PubMed score by year
PubTator Score  24.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer