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Tbio
BTD
Biotinidase

Protein Classes
Protein Summary
Description
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303498
  • ENSP00000306477
  • ENSG00000169814
  • ENST00000383778
  • ENSP00000373288
  • ENST00000427382
  • ENSP00000397113
  • ENST00000437172
  • ENSP00000400995
  • ENST00000449107
  • ENSP00000388212
  • ENST00000643237
  • ENSP00000495254
  • ENST00000646371
  • ENSP00000495866
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.9
co-expressed gene
0.79
transcription factor binding site profile
0.77
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (12)
Biotin transport and metabolism (R-HSA-196780)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biotin transport and metabolism
Reactome
Defective BTD causes biotidinase deficiency
Reactome
Defects in biotin (Btn) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Biotin transport and metabolism
Defective BTD causes biotidinase deficiency
Defects in biotin (Btn) metabolism
Defects in vitamin and cofactor metabolism
Disease
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (44)
1 – 10 of 44
SERPINC1
Tclin
Novelty: 0.00010169
p_int: 0.965190884
p_ni: 0.034808677
p_wrong: 4.4e-7
Score: 0.37
Data Source: BioPlex,STRINGDB
DHFR2
Tbio
Family: Enzyme
Novelty: 0.03421403
p_int: 0.94661893
p_ni: 0.05338107
Data Source: BioPlex
MYO1D
Tbio
Novelty: 0.03268828
p_int: 0.945770079
p_ni: 0.054229921
Score: 0.239
Data Source: BioPlex,STRINGDB
FAM19A2
Tdark
Novelty: 0.31987814
p_int: 0.887007571
p_ni: 0.112992429
Data Source: BioPlex
ERP44
Tbio
Novelty: 0.02934854
p_int: 0.877741427
p_ni: 0.122258573
Score: 0.223
Data Source: BioPlex,STRINGDB
CST5
Tbio
Novelty: 0.05255793
p_int: 0.769175725
p_ni: 0.230822977
p_wrong: 0.000001298
Data Source: BioPlex
UCN3
Tbio
Novelty: 0.01259023
p_int: 0.769175725
p_ni: 0.230822977
p_wrong: 0.000001298
Data Source: BioPlex
HLCS
Tchem
Family: Enzyme
Novelty: 0.00489358
Score: 0.988
Data Source: STRINGDB
AASS
Tbio
Family: Enzyme
Novelty: 0.04078858
Score: 0.82
Data Source: STRINGDB
MCCC1
Tbio
Family: Enzyme
Novelty: 0.01062574
Score: 0.82
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.00

PubMed score by year
PubTator Score  460.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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