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Tbio
CCL24
C-C motif chemokine 24

Protein Summary
Description
Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3. This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222902
  • ENSP00000222902
  • ENSG00000106178
  • ENST00000416943
  • ENSP00000400533

Symbol
  • MPIF2
  • SCYA24
  • Ckb-6
  • MPIF2
  • MPIF-2
  • SCYA24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.78
tissue
0.59
biological term
0.51
gene perturbation
0.48
disease
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.58   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.58   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
5
92.6
eosinophil percentage of leukocytes
2
5
5
75.8
sum of eosinophil and basophil counts
1
2
2
68.6
eosinophil percentage of granulocytes
1
2
2
68.3
neutrophil percentage of granulocytes
1
1
1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
92.6
eosinophil percentage of leukocytes
5
75.8
sum of eosinophil and basophil counts
2
68.6
eosinophil percentage of granulocytes
2
68.3
neutrophil percentage of granulocytes
1
3.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 24
VGNC:13635
472418
Mouse
MGI:1928953
56221
Rat
RGD:1310245
288593
Dog
C-C motif chemokine ligand 24
VGNC:38886
445452
Horse
C-C motif chemokine ligand 24
VGNC:16200
100061208
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 24
Mouse
Rat
Dog
C-C motif chemokine ligand 24
Horse
C-C motif chemokine ligand 24
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00175-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Protein-Protein Interactions (87)
1 – 10 of 87
CCR3
Tchem
Family: GPCR
Novelty: 0.00197059
Score: 0.97
Data Source: STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
Score: 0.819
Data Source: STRINGDB
XCR1
Tbio
Family: GPCR
Novelty: 0.00971657
Score: 0.802
Data Source: STRINGDB
CCR2
Tchem
Family: GPCR
Novelty: 0.0006525
Score: 0.802
Data Source: STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.8
Data Source: STRINGDB
CCR8
Tchem
Family: GPCR
Novelty: 0.00525007
Score: 0.784
Data Source: STRINGDB
CCL21
Tbio
Novelty: 0.00130736
Score: 0.784
Data Source: STRINGDB
CXCR3
Tchem
Family: GPCR
Novelty: 0.00100538
Score: 0.781
Data Source: STRINGDB
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.774
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00224501
Score: 0.76
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.58

PubMed score by year
PubTator Score  83.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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