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Tbio
LAMA2
Laminin subunit alpha-2

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421865
  • ENSP00000400365
  • ENSG00000196569

Symbol
  • LAMM
  • LAMM
  • MDC1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.97
disease perturbation
0.83
cellular component
0.81
disease
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 480.37   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 480.37   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
2
4
19.4
99.3
Myopia
3
1
0
1.7
81.7
age at onset
1
1
0
19.4
74.9
smoking status measurement
1
1
1
69
Abnormality of refraction
1
1
1
68.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
4
19.4
99.3
Myopia
0
1.7
81.7
age at onset
0
19.4
74.9
smoking status measurement
1
69
Abnormality of refraction
1
68.4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Laminin interactions
Reactome
MET activates PTK2 signaling
Reactome
MET promotes cell motility
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Laminin interactions
MET activates PTK2 signaling
MET promotes cell motility
Protein-Protein Interactions (129)
1 – 10 of 129
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.997
Data Source: Reactome,STRINGDB
DMD
Tclin
Novelty: 0.00025661
Score: 0.977
Data Source: Reactome,STRINGDB
ITGA7
Tbio
Novelty: 0.01243073
Score: 0.969
Data Source: STRINGDB
NID1
Tbio
Novelty: 0.00169075
Score: 0.962
Data Source: STRINGDB
ITGA3
Tchem
Novelty: 0.00505981
Score: 0.955
Data Source: STRINGDB
ITGA6
Tbio
Novelty: 0.00217985
Score: 0.955
Data Source: STRINGDB
UTRN
Tbio
Novelty: 0.0018541
Score: 0.955
Data Source: STRINGDB
LAMB1
Tbio
Novelty: 0.0104285
Score: 0.951
Data Source: Reactome,STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.95
Data Source: STRINGDB
AGRN
Tbio
Novelty: 0.00156441
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  480.37

PubMed score by year
PubTator Score  288.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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