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Tbio
DNAI2
Dynein intermediate chain 2, axonemal

Protein Summary
Description
Part of the dynein complex of respiratory cilia. The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311014
  • ENSP00000308312
  • ENSG00000171595
  • ENST00000446837
  • ENSP00000400252
  • ENST00000582036
  • ENSP00000461950

Symbol
  • DIC2
  • CILD9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.64
cell type or tissue
0.52
tissue
0.52
transcription factor
0.52
cellular component
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.59   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.59   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685574
432611
Rat
RGD:1359602
360654
Dog
dynein axonemal intermediate chain 2
VGNC:40021
483284
Horse
dynein axonemal intermediate chain 2
VGNC:17242
100060918
Cow
dynein axonemal intermediate chain 2
VGNC:28130
534479
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
dynein axonemal intermediate chain 2
Horse
dynein axonemal intermediate chain 2
Cow
dynein axonemal intermediate chain 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZS0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (112)
1 – 10 of 112
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.996504601
p_ni: 0.003495399
Data Source: BioPlex
CCT6A
Tbio
Novelty: 0.02368046
p_int: 0.989584132
p_ni: 0.010415868
Score: 0.22
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.983579256
p_ni: 0.016420744
Score: 0.685
Data Source: BioPlex,STRINGDB
STIP1
Tbio
Novelty: 0.00590952
p_int: 0.980650978
p_ni: 0.019349022
Score: 0.191
Data Source: BioPlex,STRINGDB
CCT5
Tbio
Novelty: 0.02369118
p_int: 0.967459447
p_ni: 0.032540553
Score: 0.611
Data Source: BioPlex,STRINGDB
CCT7
Tbio
Novelty: 0.02247038
p_int: 0.96159628
p_ni: 0.03840372
Score: 0.663
Data Source: BioPlex,STRINGDB
CCT6B
Tdark
Novelty: 0.28933315
p_int: 0.949592849
p_ni: 0.050407151
Data Source: BioPlex
TCP1
Tbio
Novelty: 0.00395241
p_int: 0.925218479
p_ni: 0.074781521
Score: 0.339
Data Source: BioPlex,STRINGDB
CCT4
Tbio
Novelty: 0.01176123
p_int: 0.878558785
p_ni: 0.121441215
Score: 0.356
Data Source: BioPlex,STRINGDB
MYO1D
Tbio
Novelty: 0.03263543
p_int: 0.801103407
p_ni: 0.198896593
Score: 0.21
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  33.59

PubMed score by year
PubTator Score  12.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer