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Tbio
SLC25A13
Calcium-binding mitochondrial carrier protein Aralar2

Protein Summary
Description
Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871). This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265631
  • ENSP00000265631
  • ENSG00000004864
  • ENST00000416240
  • ENSP00000400101

Symbol
  • ARALAR2
  • CTLN2
  • CITRIN
  • ARALAR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.87
biological process
0.85
protein domain
0.85
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.23   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.23   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
2
1
2
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
2
11.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Aspartate and asparagine metabolism (R-HSA-8963693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aspartate and asparagine metabolism
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Aspartate and asparagine metabolism
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (59)
1 – 10 of 59
SLC25A12
Tbio
Family: Transporter
Novelty: 0.01205065
p_int: 0.897425739
p_ni: 0.102574261
Score: 0.697
Data Source: BioPlex,STRINGDB
TIMM13
Tdark
Family: Enzyme
Novelty: 0.04802297
Score: 0.989
Data Source: STRINGDB
TIMM8A
Tbio
Family: Enzyme
Novelty: 0.00954602
Score: 0.98
Data Source: STRINGDB
TIMM23
Tbio
Family: Enzyme
Novelty: 0.06463808
Score: 0.979
Data Source: STRINGDB
ACO2
Tbio
Family: Enzyme
Novelty: 0.00276725
Score: 0.959
Data Source: STRINGDB
TIMM22
Tbio
Family: Enzyme
Novelty: 0.12627933
Score: 0.928
Data Source: STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.01052213
Score: 0.927
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
Score: 0.927
Data Source: STRINGDB
CYC1
Tbio
Novelty: 0.01369865
Score: 0.92
Data Source: STRINGDB
TIMM8B
Tbio
Family: Enzyme
Novelty: 0.02843625
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  203.23

PubMed score by year
PubTator Score  207.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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