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Tbio
NCOA2
Nuclear receptor coactivator 2

Protein Summary
Description
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate res ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000452400
  • ENSP00000399968
  • ENSG00000140396

Symbol
  • BHLHE75
  • SRC2
  • TIF2
  • SRC2
  • TIF2
  • GRIP1
  • KAT13C
  • NCoA-2
  • bHLHe75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
ligand (protein) perturbation
0.99
molecular function
0.95
hub protein
0.92
transcription factor binding site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.48   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.48   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
1
2
79.9
sex hormone-binding globulin measurement
3
2
3
71
self reported educational attainment
1
1
1
65.5
lymphocyte count
1
1
1
46.8
airway imaging measurement
1
1
1
33
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
79.9
sex hormone-binding globulin measurement
3
71
self reported educational attainment
1
65.5
lymphocyte count
1
46.8
airway imaging measurement
1
33
Protein Data Bank (271)
1 – 5 of 271
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (67)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Bile acid and bile salt metabolism
Reactome
Biological oxidations
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Bile acid and bile salt metabolism
Biological oxidations
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (236)
1 – 10 of 236
MAGEA10
Tbio
Novelty: 0.05364393
p_int: 1
Score: 0.422
Data Source: BioPlex,STRINGDB
NR1I3
Tchem
Family: NR
Novelty: 0.00221694
p_int: 0.991722029
p_ni: 0.008275853
p_wrong: 0.000002118
Score: 0.827
Data Source: BioPlex,STRINGDB
SLA
Tbio
Novelty: 0.01923631
p_int: 0.962915444
p_ni: 0.007022818
p_wrong: 0.030061738
Score: 0.68
Data Source: BioPlex,STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.999
Data Source: Reactome,STRINGDB
NR3C1
Tclin
Family: NR
Novelty: 0.00029396
Score: 0.998
Data Source: STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00010033
Score: 0.998
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.997
Data Source: Reactome,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.995
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.987
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  187.48

PubMed score by year
PubTator Score  221.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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