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Tbio
FGF16
Fibroblast growth factor 16

Protein Summary
Description
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000439435
  • ENSP00000399324
  • ENSG00000196468

Symbol
  • MF4
  • FGF-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.77
disease perturbation
0.74
virus perturbation
0.72
gene perturbation
0.69
cell type or tissue
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.96   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.96   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fibroblast growth factor 16
705612
Mouse
MGI:1931627
80903
Rat
RGD:71052
60464
Dog
fibroblast growth factor 16
VGNC:40843
491974
Horse
fibroblast growth factor 16
VGNC:18013
100071790
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fibroblast growth factor 16
Mouse
Rat
Dog
fibroblast growth factor 16
Horse
fibroblast growth factor 16
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43320-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (82)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 60
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (99)
1 – 10 of 99
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
Score: 0.987
Data Source: STRINGDB
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
Score: 0.983
Data Source: STRINGDB
FGFR3
Tclin
Family: Kinase
Novelty: 0.00071612
Score: 0.981
Data Source: STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.955
Data Source: STRINGDB
FGF19
Tbio
Novelty: 0.00317427
Score: 0.94
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.938
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.936
Data Source: STRINGDB
FRS2
Tbio
Novelty: 0.00654052
Score: 0.933
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.931
Data Source: STRINGDB
FGF18
Tbio
Novelty: 0.00802997
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.96

PubMed score by year
PubTator Score  35.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer