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Tbio
CYR61
Protein CYR61

Protein Summary
Description
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000451137
  • ENSP00000398736
  • ENSG00000142871

Symbol
  • CCN1
  • GIG1
  • IGFBP10
  • GIG1
  • CYR61
  • IGFBP10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
biological process
0.99
transcription factor perturbation
0.99
protein domain
0.97
small molecule perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.46   (req: < 5)
Gene RIFs: 208   (req: <= 3)
Antibodies: 546   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.46   (req: >= 5)
Gene RIFs: 208   (req: > 3)
Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (878)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (42)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (201)
1 – 10 of 201
APOD
Tbio
Novelty: 0.00362142
p_int: 0.847533669
p_ni: 0.000006602
p_wrong: 0.152459729
Score: 0.403
Data Source: BioPlex,STRINGDB
IGFBP7
Tbio
Novelty: 0.00155903
Score: 0.98
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.0000437
Score: 0.958
Data Source: STRINGDB
ITGB5
Tbio
Novelty: 0.02400591
Score: 0.95
Data Source: STRINGDB
ITGAV
Tchem
Novelty: 0.00217401
Score: 0.949
Data Source: STRINGDB
IGFBP3
Tchem
Novelty: 0.00042672
Score: 0.948
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00002829
Score: 0.94
Data Source: STRINGDB
IGFBP5
Tchem
Novelty: 0.00287201
Score: 0.937
Data Source: STRINGDB
GAS6
Tbio
Novelty: 0.00291371
Score: 0.936
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00057391
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  341.46

PubMed score by year
PubTator Score  311.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPC
1-70
DHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSL
70-140
PNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRL
140-210
PVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSL
210-280
KKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMI
280-350
QSCKCNYNCPHANEAAFPFYRLFNDIHKFRD
350-381
MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD