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Tbio
CD44
CD44 antigen

Protein Summary
Description
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
biological process
0.99
gene perturbation
0.94
microRNA
0.94
PubMedID
0.86


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8440.61   (req: < 5)
Gene RIFs: 982   (req: <= 3)
Antibodies: 4804   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8440.61   (req: >= 5)
Gene RIFs: 982   (req: > 3)
Antibodies: 4804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD44 molecule
VGNC:3158
451122
Macaque
CD44 molecule (Indian blood group)
717204
Mouse
MGI:88338
12505
Rat
RGD:2307
25406
Dog
CD44 molecule
VGNC:51860
403939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD44 molecule
Macaque
CD44 molecule (Indian blood group)
Mouse
Rat
Dog
CD44 molecule
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16070-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (95)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
Degradation of the extracellular matrix
Extracellular matrix organization
Glycosaminoglycan metabolism
Protein-Protein Interactions (765)
1 – 10 of 765
VCAN
Tbio
Novelty: 0.00110986
p_int: 0.999999564
p_ni: 4.35e-7
p_wrong: 1e-9
Score: 0.844
Data Source: BioPlex,STRINGDB
GMEB2
Tdark
Family: TF
Novelty: 0.1945427
p_int: 0.99999877
p_ni: 1.25e-7
p_wrong: 0.000001105
Score: 0.439
Data Source: BioPlex,STRINGDB
FGF2
Tchem
Novelty: 0.00007856
p_int: 0.999998694
p_ni: 6.1e-8
p_wrong: 0.000001246
Score: 0.89
Data Source: BioPlex,STRINGDB
GMEB1
Tbio
Family: TF
Novelty: 0.10522678
p_int: 0.999998072
p_ni: 0.000001921
p_wrong: 7e-9
Score: 0.439
Data Source: BioPlex,STRINGDB
DHRS2
Tbio
Family: Enzyme
Novelty: 0.002032
p_int: 0.999997811
p_ni: 0.000002189
Score: 0.188
Data Source: BioPlex,STRINGDB
METTL8
Tdark
Family: Enzyme
Novelty: 0.24190691
p_int: 0.99999713
p_ni: 0.000002857
p_wrong: 1.3e-8
Data Source: BioPlex
IRAK3
Tchem
Family: Kinase
Novelty: 0.01001206
p_int: 0.999984325
p_ni: 0.000015562
p_wrong: 1.12e-7
Score: 0.263
Data Source: BioPlex,STRINGDB
TCAF2
Tbio
Family: Enzyme
Novelty: 0.37070492
p_int: 0.999976722
p_ni: 0.000023278
Data Source: BioPlex
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.99997619
p_ni: 0.00002381
Data Source: BioPlex
AMPD2
Tchem
Family: Enzyme
Novelty: 0.01510718
p_int: 0.999955489
p_ni: 0.000044508
p_wrong: 3e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  8440.61

PubMed score by year
PubTator Score  4570.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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