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Tbio
SOX5
Transcription factor SOX-5

Protein Summary
Description
Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381381
  • ENSP00000370788
  • ENSG00000134532
  • ENST00000396007
  • ENSP00000379328
  • ENST00000451604
  • ENSP00000398273
  • ENST00000541536
  • ENSP00000441973
  • ENST00000545921
  • ENSP00000443520
  • ENST00000546136
  • ENSP00000437487
  • ENST00000646273
  • ENSP00000493866

Symbol
  • L-SOX5
  • LAMSHF
  • L-SOX5B
  • L-SOX5F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.86
transcription factor
0.84
microRNA
0.8
histone modification site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.09   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.09   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neural Crest Differentiation
WikiPathways
Endochondral Ossification
WikiPathways
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Name
Explore in Pharos
Explore in Source
Neural Crest Differentiation
Endochondral Ossification
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Protein-Protein Interactions (111)
1 – 10 of 111
SOX6
Tbio
Family: TF
Novelty: 0.00692878
p_int: 1
Score: 0.568
Data Source: BioPlex,STRINGDB
SOX13
Tbio
Family: TF
Novelty: 0.03069993
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.858
Data Source: BioPlex,STRINGDB
CEP85
Tdark
Novelty: 0.46332046
p_int: 0.999730962
p_ni: 0.000269038
p_wrong: 1e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
SOX1
Tbio
Family: TF
Novelty: 0.00791998
p_int: 0.990679215
p_wrong: 0.009320785
Score: 0.574
Data Source: BioPlex,STRINGDB
ANKRD40
Tdark
p_int: 0.977851469
p_ni: 0.022148531
Score: 0.163
Data Source: BioPlex,STRINGDB
SOX11
Tbio
Family: TF
Novelty: 0.00641271
p_int: 0.810335585
p_wrong: 0.189664415
Score: 0.59
Data Source: BioPlex,STRINGDB
ARID5A
Tbio
Family: TF
Novelty: 0.14769664
Score: 0.806
Data Source: STRINGDB
ETNK1
Tbio
Family: Kinase
Novelty: 0.02426622
Score: 0.8
Data Source: STRINGDB
COL2A1
Tbio
Novelty: 0.00119609
Score: 0.745
Data Source: STRINGDB
NEUROG1
Tbio
Family: TF
Novelty: 0.00695422
Score: 0.718
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.09

PubMed score by year
PubTator Score  76.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPV
1-70
SLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLA
70-140
DVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLT
140-210
SLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMI
210-280
PVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQ
280-350
VSPGGKLPGIPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPAL
350-420
RINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLN
420-490
NCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPM
490-560
NAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPK
560-630
RTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSS
630-700
SPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN
700-763
MLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN