Tbio IL34 Interleukin-34

Protein Summary

Description

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

Uniprot Accession IDs

• Q6ZMJ4
• B2RC28
• B2Z4A8
• B2ZC70
• Q8N6L2
• IL-34

Gene Name

• IL34

Ensembl ID

• ENST00000288098
• ENSP00000288098
• ENSG00000157368
• ENST00000429149
• ENSP00000397863

Symbol

• C16orf77
• IL-34
• C16orf77

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.6
tissue sample	0.53
cell type or tissue	0.51
PubMedID	0.5
biological process	0.47

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.92   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 350   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.92   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (6)

Reactome (4)

KEGG (2)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Other interleukin signaling	287 targets	R-HSA-449836
Reactome	Signaling by Interleukins	619 targets	R-HSA-449147

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Other interleukin signaling	287 targets	R-HSA-449836
Signaling by Interleukins	619 targets	R-HSA-449147

Gene Ontology Terms (13)

Functions (4)

Components (2)

Processes (7)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
macrophage colony-stimulating factor receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
cytokine activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
growth factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (35)

Explore Interacting Targets

1 – 10 of 35

• See Interactions on String-DB

CSF1R

Tclin

Family: Kinase

Novelty: 0.00058475

Score: 0.998

Data Source: Reactome,STRINGDB

CSF1

Tbio

Novelty: 0.00068583

Score: 0.974

Data Source: Reactome,STRINGDB

PTPRZ1

Tbio

Family: Enzyme

Novelty: 0.00645203

Score: 0.932

Data Source: Reactome,STRINGDB

SDC1

Tbio

Novelty: 0.0006457

Score: 0.907

Data Source: Reactome,STRINGDB

TLR3

Tbio

Novelty: 0.00056226

Score: 0.689

Data Source: STRINGDB

TRAF3

Tbio

Novelty: 0.00292884

Score: 0.549

Data Source: STRINGDB

IL1B

Tclin

Novelty: 0.00003644

Score: 0.536

Data Source: STRINGDB

DNALI1

Tdark

Novelty: 0.25184889

Score: 0.526

Data Source: STRINGDB

TREM2

Tbio

Novelty: 0.00295722

Score: 0.517

Data Source: STRINGDB

SPI1

Tbio

Family: TF

Novelty: 0.0008303

Score: 0.515

Data Source: STRINGDB

Publication Statistics

PubMed Score  98.92

PubMed score by year

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PubTator Score  65.56

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEG

1-70

VFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSP

70-140

KVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAAT

140-210

QLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP

210-242

MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
Cytokine
Glycoprotein
Growth factor
Immunity
Inflammatory response
Innate immunity
Polymorphism