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Tbio
KY
Kyphoscoliosis peptidase

Protein Summary
Description
Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity). The protein encoded by this gene belongs to the transglutaminase-like superfamily. The protein is involved in the function, maturation and stabilization of the neuromuscular junction and may be required for normal muscle growth. Mutations in this gene are associated with myopathy, myofibrillar, 7. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423778
  • ENSP00000397598
  • ENSG00000174611
  • ENST00000508956
  • ENSP00000421297

Symbol
  • MFM7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.77
histone modification site profile
0.64
cell line
0.57
gene perturbation
0.53
PubMedID
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.69   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.69   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
FLNC
Tbio
Novelty: 0.00463205
Score: 0.772
Data Source: STRINGDB
MYBPC1
Tbio
Novelty: 0.041267
Score: 0.767
Data Source: STRINGDB
MSS51
Tbio
Novelty: 0.06388791
Score: 0.715
Data Source: STRINGDB
ANKRD29
Tdark
Novelty: 1.29202649
Score: 0.694
Data Source: STRINGDB
KLHDC1
Tbio
Novelty: 1.2348626
Score: 0.648
Data Source: STRINGDB
SPSB3
Tdark
Novelty: 0.07215887
Score: 0.615
Data Source: STRINGDB
NCOA7
Tbio
Novelty: 0.08842763
Score: 0.554
Data Source: STRINGDB
HAS3
Tbio
Family: Enzyme
Novelty: 0.03898687
Score: 0.546
Data Source: STRINGDB
HAS1
Tbio
Family: Enzyme
Novelty: 0.02014779
Score: 0.546
Data Source: STRINGDB
HAS2
Tbio
Family: Enzyme
Novelty: 0.0025539
Score: 0.546
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.69

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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