Tbio NTF3 Neurotrophin-3

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Neurotrophic Factor / Neurotrophin-3

DTO Classes

Protein / Signaling / Growth Factor / Neurotrophic Factor / Neurotrophin-3

Protein Summary

Description

Seems to promote the survival of visceral and proprioceptive sensory neurons. The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P20783
• B7Z1T5
• Q6FH50
• NT-3

Gene Name

• NTF3

Ensembl ID

• ENST00000331010
• ENSP00000328738
• ENSG00000185652
• ENST00000423158
• ENSP00000397297

Symbol

• NT3
• HDNF
• NGF2
• NT-3
• NGF-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
gene perturbation	0.97
biological term	0.77
disease	0.77
chemical	0.73

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1294.83   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 578   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1294.83   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (64)

Reactome (10)

KEGG (4)

PathwayCommons (10)

WikiPathways (40)

Activated NTRK3 signals through PI3K (R-HSA-9603381)

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Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated NTRK3 signals through PI3K	6 targets	R-HSA-9603381
Reactome	Activated NTRK3 signals through PLCG1	3 targets	R-HSA-9034793
Reactome	Activated NTRK3 signals through RAS	8 targets	R-HSA-9034864
Reactome	NTF3 activates NTRK2 (TRKB) signaling	2 targets	R-HSA-9025046
Reactome	NTF3 activates NTRK3 signaling	2 targets	R-HSA-9034013

Name	Explore in Pharos	Explore in Source
Activated NTRK3 signals through PI3K	6 targets	R-HSA-9603381
Activated NTRK3 signals through PLCG1	3 targets	R-HSA-9034793
Activated NTRK3 signals through RAS	8 targets	R-HSA-9034864
NTF3 activates NTRK2 (TRKB) signaling	2 targets	R-HSA-9025046
NTF3 activates NTRK3 signaling	2 targets	R-HSA-9034013

Gene Ontology Terms (36)

Functions (4)

Components (6)

Processes (26)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
chemoattractant activity	Inferred from Direct Assay (IDA)	BHF-UCL
growth factor activity	Inferred from Direct Assay (IDA)	BHF-UCL
signaling receptor binding	Traceable Author Statement (TAS)	ProtInc
neurotrophin receptor binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (199)

Explore Interacting Targets

1 – 10 of 199

• See Interactions on String-DB

KCTD18

Tdark

Novelty: 1.42857143

p_int: 0.999607417

p_ni: 0.000004662

p_wrong: 0.000387921

Data Source: BioPlex

MAD2L1BP

Tbio

Novelty: 0.86956522

p_int: 0.983134945

p_ni: 0.000349583

p_wrong: 0.016515472

Score: 0.519

Data Source: BioPlex,STRINGDB

METTL5

Tdark

Family: Enzyme

Novelty: 0.4

p_int: 0.976928626

p_ni: 1.4e-8

p_wrong: 0.02307136

Data Source: BioPlex

HSPA5

Tchem

Novelty: 0.00051387

p_int: 0.973868514

p_ni: 0.026131486

Data Source: BioPlex

PYGB

Tbio

Family: Enzyme

Novelty: 0.0023816

p_int: 0.899326478

p_ni: 0.100673522

Score: 0.201

Data Source: BioPlex,STRINGDB

PYGL

Tchem

Family: Enzyme

Novelty: 0.01061209

p_int: 0.831239695

p_ni: 0.168760306

Score: 0.519

Data Source: BioPlex,STRINGDB

NTRK3

Tclin

Family: Kinase

Novelty: 0.00241438

Score: 0.998

Data Source: Reactome,STRINGDB

NTRK2

Tclin

Family: Kinase

Novelty: 0.00060827

Score: 0.997

Data Source: Reactome,STRINGDB

NTRK1

Tclin

Family: Kinase

Novelty: 0.0004431

Score: 0.996

Data Source: STRINGDB

NGFR

Tclin

Novelty: 0.00089072

Score: 0.996

Data Source: STRINGDB

Publication Statistics

PubMed Score  1294.83

PubMed score by year

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PubTator Score  548.99

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPR

1-70

EPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYA

70-140

EHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDD

140-210

KHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

210-257

MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Glycoprotein
Growth factor
Polymorphism
Reference proteome
Secreted