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Tbio
SCN1B
Sodium channel subunit beta-1

Protein Summary
Description
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Isoform 2: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth. Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262631
  • ENSP00000262631
  • ENSG00000105711
  • ENST00000415950
  • ENSP00000396915
  • ENST00000638536
  • ENSP00000492022

Symbol
  • ATFB13
  • BRGDA5
  • EIEE52
  • GEFSP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
small molecule perturbation
0.83
disease perturbation
0.79
biological process
0.77
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.19   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.19   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Gene Ontology Terms (33)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
UBB
Tbio
Novelty: 0.00661254
p_int: 0.999971749
p_ni: 0.000027894
p_wrong: 3.58e-7
Data Source: BioPlex
RNF126
Tbio
Family: Enzyme
Novelty: 0.08123801
p_int: 0.993295094
p_ni: 0.006703219
p_wrong: 0.000001687
Data Source: BioPlex
DHRS7
Tbio
Family: Enzyme
Novelty: 0.16713756
p_int: 0.988381985
p_ni: 0.011614421
p_wrong: 0.000003594
Data Source: BioPlex
RNF115
Tbio
Family: Enzyme
Novelty: 0.03523706
p_int: 0.901450777
p_ni: 0.098406376
p_wrong: 0.000142847
Data Source: BioPlex
AMFR
Tbio
Family: Enzyme
Novelty: 0.00533547
p_int: 0.80769717
p_ni: 0.19230283
Data Source: BioPlex
FANCD2
Tbio
Novelty: 0.00316101
p_int: 0.804154692
p_ni: 0.195845308
Data Source: BioPlex
GET4
Tbio
Novelty: 0.03516005
p_int: 0.794186077
p_ni: 0.205813923
Data Source: BioPlex
TTC1
Tbio
Novelty: 0.01389711
p_int: 0.790481548
p_ni: 0.209518259
p_wrong: 1.93e-7
Data Source: BioPlex
TELO2
Tbio
Novelty: 0.05515633
p_int: 0.781671982
p_ni: 0.218328018
Data Source: BioPlex
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.76407897
p_ni: 0.23592103
Data Source: BioPlex
Publication Statistics
PubMed Score  94.19

PubMed score by year
PubTator Score  61.1

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer