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Tclin
DHFR
Dihydrofolate reductase

Protein Summary
Description
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000439211
  • ENSP00000396308
  • ENSG00000228716
  • ENST00000504396
  • ENSP00000421334
  • ENST00000505337
  • ENSP00000426474

Symbol
  • DYR
  • DHFRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
disease
0.95
drug
0.94
histone modification site profile
0.93
kinase perturbation
0.81


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1301.61   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1301.61   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 518
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Structure (77 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00374-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 77
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G1/S Transition
Reactome
G1/S-Specific Transcription
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G1/S Transition
G1/S-Specific Transcription
Metabolism
Gene Ontology Terms (25)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (235)
1 – 10 of 235
TYMS
Tclin
Family: Enzyme
Novelty: 0.00087522
Score: 0.999
Data Source: STRINGDB
FPGS
Tchem
Family: Enzyme
Novelty: 0.0108601
Score: 0.99
Data Source: STRINGDB
GART
Tclin
Novelty: 0.00524985
Score: 0.988
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.983
Data Source: STRINGDB
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00234505
Score: 0.981
Data Source: STRINGDB
MTHFD1
Tbio
Family: Enzyme
Novelty: 0.0071938
Score: 0.979
Data Source: STRINGDB
SPR
Tchem
Family: Enzyme
Novelty: 0.02144934
Score: 0.977
Data Source: STRINGDB
QDPR
Tchem
Family: Enzyme
Novelty: 0.00836889
Score: 0.974
Data Source: STRINGDB
CBR1
Tchem
Family: Enzyme
Novelty: 0.0062295
Score: 0.971
Data Source: STRINGDB
MTHFD1L
Tbio
Family: Enzyme
Novelty: 0.01548353
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  1301.61

PubMed score by year
PubTator Score  1541.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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