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Tbio
SNX10
Sorting nexin-10

Protein Summary
Description
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338523
  • ENSP00000343709
  • ENSG00000086300
  • ENST00000396376
  • ENSP00000379661
  • ENST00000409838
  • ENSP00000386540
  • ENST00000446848
  • ENSP00000395474

Symbol
  • OPTB8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
transcription factor perturbation
0.91
transcription factor binding site profile
0.82
transcription factor
0.78
gene perturbation
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.41   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.41   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
1
2
96
BMI-adjusted waist-hip ratio
3
1
4
93.6
sex hormone-binding globulin measurement
4
2
4
92.6
high density lipoprotein cholesterol measurement
2
2
2
70.8
triglyceride measurement
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
96
BMI-adjusted waist-hip ratio
4
93.6
sex hormone-binding globulin measurement
4
92.6
high density lipoprotein cholesterol measurement
2
70.8
triglyceride measurement
1
56.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 10
VGNC:4511
463302
Macaque
sorting nexin 10
701684
Mouse
MGI:1919232
71982
Rat
RGD:1305782
297096
Dog
sorting nexin 10
VGNC:46620
475261
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 10
Macaque
sorting nexin 10
Mouse
Rat
Dog
sorting nexin 10
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5X0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (39)
1 – 10 of 39
VPS35
Tbio
Novelty: 0.00729892
Score: 0.845
Data Source: STRINGDB
PLEKHM1
Tbio
Novelty: 0.02298085
Score: 0.794
Data Source: STRINGDB
VPS26A
Tbio
Novelty: 0.01804654
Score: 0.751
Data Source: STRINGDB
CLCN7
Tchem
Family: IC
Novelty: 0.00764796
Score: 0.736
Data Source: STRINGDB
OSTM1
Tbio
Novelty: 0.03033192
Score: 0.711
Data Source: STRINGDB
VPS26B
Tdark
Novelty: 0.25702869
Score: 0.699
Data Source: STRINGDB
TCIRG1
Tbio
Family: Enzyme
Novelty: 0.00814253
Score: 0.675
Data Source: STRINGDB
SNX20
Tdark
Novelty: 0.28934317
Score: 0.653
Data Source: STRINGDB
SNX14
Tbio
Novelty: 0.10690692
Score: 0.64
Data Source: STRINGDB
VPS29
Tbio
Novelty: 0.01335106
Score: 0.632
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.41

PubMed score by year
PubTator Score  14.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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