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Tchem
LPAR3
Lysophosphatidic acid receptor 3

Protein Summary
Description
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370611
  • ENSP00000359643
  • ENSG00000171517
  • ENST00000440886
  • ENSP00000395389

Symbol
  • EDG7
  • LPA3
  • EDG7
  • GPCR
  • LPA3
  • Edg-7
  • LP-A3
  • HOFNH30
  • RP4-678I3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
virus perturbation
0.97
biological process
0.87
transcription factor perturbation
0.84
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.24   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.24   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
94.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
94.4
Pathways (44)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (394)
1 – 10 of 394
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.52190272
p_int: 0.934736049
p_ni: 0.000003001
p_wrong: 0.065260951
Data Source: BioPlex
LPAR4
Tchem
Family: GPCR
Novelty: 0.02200758
Score: 0.989
Data Source: STRINGDB
LPAR5
Tchem
Family: GPCR
Novelty: 0.01883439
Score: 0.987
Data Source: STRINGDB
LPAR6
Tchem
Family: GPCR
Novelty: 0.01801122
Score: 0.98
Data Source: STRINGDB
P2RY10
Tchem
Family: GPCR
Novelty: 0.12674578
Score: 0.961
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.945
Data Source: STRINGDB
GNA14
Tbio
Novelty: 0.0587776
Score: 0.929
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.929
Data Source: STRINGDB
RXFP4
Tbio
Family: GPCR
Novelty: 0.05054041
Score: 0.929
Data Source: STRINGDB
GPR68
Tchem
Family: GPCR
Novelty: 0.01309603
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  172.24

PubMed score by year
PubTator Score  117.99

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer