You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PPT1
Palmitoyl-protein thioesterase 1

Protein Summary
Description
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748). The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000449045
  • ENSP00000392293
  • ENSG00000131238
  • ENST00000529905
  • ENSP00000432053
  • ENST00000642050
  • ENSP00000493153

Symbol
  • CLN1
  • PPT
  • PPT
  • CLN1
  • INCL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.96
virus perturbation
0.96
biological process
0.93
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.34   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.34   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
10.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Protein-Protein Interactions (107)
1 – 10 of 107
CLN3
Tbio
Novelty: 0.00242393
Score: 0.907
Data Source: STRINGDB
MECR
Tbio
Family: Enzyme
Novelty: 0.01395965
Score: 0.905
Data Source: STRINGDB
PPT2
Tbio
Family: Enzyme
Novelty: 0.00829249
Score: 0.861
Data Source: STRINGDB
LYPLA1
Tchem
Family: Enzyme
Novelty: 0.01217068
Score: 0.838
Data Source: STRINGDB
CLN5
Tbio
Novelty: 0.01124343
Score: 0.835
Data Source: STRINGDB
CLN6
Tbio
Novelty: 0.01095683
Score: 0.832
Data Source: STRINGDB
CLN8
Tbio
Novelty: 0.01721625
Score: 0.818
Data Source: STRINGDB
LYPLA2
Tchem
Family: Enzyme
Novelty: 0.05436006
Score: 0.77
Data Source: STRINGDB
TPP1
Tbio
Family: Enzyme
Novelty: 0.00590008
Score: 0.768
Data Source: STRINGDB
SGSH
Tbio
Family: Enzyme
Novelty: 0.00670111
Score: 0.766
Data Source: STRINGDB
Publication Statistics
PubMed Score  389.34

PubMed score by year
PubTator Score  215.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: