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Tchem
PTPN13
Tyrosine-protein phosphatase non-receptor type 13

Protein Summary
Description
Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316707
  • ENSP00000322675
  • ENSG00000163629
  • ENST00000411767
  • ENSP00000407249
  • ENST00000427191
  • ENSP00000408368
  • ENST00000436978
  • ENSP00000394794
  • ENST00000511467
  • ENSP00000426626

Symbol
  • PNP1
  • PTP1E
  • PTPL1
  • PNP1
  • FAP-1
  • PTP1E
  • PTPL1
  • PTPLE
  • PTP-BL
  • hPTP1E
  • PTP-BAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.89
kinase perturbation
0.88
gene perturbation
0.85
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.26   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.26   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-37 signaling
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-37 signaling
Metabolism
Protein-Protein Interactions (118)
1 – 10 of 118
RGS2
Tbio
Novelty: 0.00370571
p_int: 0.999999615
p_ni: 3.83e-7
p_wrong: 2e-9
Score: 0.283
Data Source: BioPlex,STRINGDB
DFFB
Tbio
Novelty: 0.00475349
p_int: 0.999946545
p_ni: 0.000053431
p_wrong: 2.4e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
EFNB1
Tbio
Novelty: 0.00523161
Score: 0.978
Data Source: STRINGDB
FAS
Tbio
Novelty: 0.00043286
Score: 0.967
Data Source: STRINGDB
FASLG
Tbio
Novelty: 0.0003303
Score: 0.964
Data Source: STRINGDB
FADD
Tbio
Novelty: 0.00137968
Score: 0.956
Data Source: STRINGDB
PLEKHA1
Tbio
Novelty: 0.03634462
Score: 0.955
Data Source: Reactome,STRINGDB
EPHB1
Tchem
Family: Kinase
Novelty: 0.01424716
Score: 0.945
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.942
Data Source: STRINGDB
PLEKHA2
Tbio
Novelty: 0.14583759
Score: 0.942
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  246.26

PubMed score by year
PubTator Score  163.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer