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Tclin
OPRM1
Mu-type opioid receptor

Protein Summary
Description
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:7905839, PubMed:7957926, PubMed:7891175, PubMed:12589820, PubMed:9689128). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, includi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229768
  • ENSP00000229768
  • ENSG00000112038
  • ENST00000330432
  • ENSP00000328264
  • ENST00000337049
  • ENSP00000338381
  • ENST00000414028
  • ENSP00000399359
  • ENST00000419506
  • ENSP00000403549
  • ENST00000428397
  • ENSP00000411903
  • ENST00000434900
  • ENSP00000394624
  • ENST00000435918
  • ENSP00000413752
  • ENST00000452687
  • ENSP00000410497
  • ENST00000518759
  • ENSP00000430260
  • ENST00000519083
  • ENSP00000431048
  • ENST00000520708
  • ENSP00000430876
  • ENST00000522236
  • ENSP00000429373
  • ENST00000522555
  • ENSP00000429719
  • ENST00000522739
  • ENSP00000428018
  • ENST00000524150
  • ENSP00000430575
  • ENST00000524163
  • ENSP00000430097

Symbol
  • MOR1
  • MOP
  • MOR
  • LMOR
  • MOR1
  • OPRM
  • M-OR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
1
biological process
0.99
ligand (chemical)
0.99
kinase
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2654.46   (req: < 5)
Gene RIFs: 402   (req: <= 3)
Antibodies: 512   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2654.46   (req: >= 5)
Gene RIFs: 402   (req: > 3)
Antibodies: 512   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2083
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 40
Approved Drugs (40)
1 – 10 of 40
naltrexone
chemical structure image
naloxone
chemical structure image
morphine
chemical structure image
levorphanol
chemical structure image
nalbuphine
chemical structure image
nalmefene
chemical structure image
butorphanol
chemical structure image
fentanyl
chemical structure image
buprenorphine
chemical structure image
loperamide
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
opioid use disorder
1
1
1
72.2
2
2
0
1.2
65.6
testosterone measurement
1
1
1
56.7
diastolic blood pressure
1
1
1
37.5
body height
1
1
1
22.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
opioid use disorder
1
72.2
0
1.2
65.6
testosterone measurement
1
56.7
diastolic blood pressure
1
37.5
body height
1
22.2
Pathways (28)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
G-protein activation
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
G-protein activation
GPCR downstream signalling
Gene Ontology Terms (65)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (456)
1 – 10 of 456
ZFYVE26
Tbio
Novelty: 0.04897973
p_int: 0.999799451
p_ni: 0.000007509
p_wrong: 0.00019304
Score: 0.239
Data Source: BioPlex,STRINGDB
MMS22L
Tbio
Novelty: 0.22570578
p_int: 0.9990965
p_ni: 0.000899655
p_wrong: 0.000003845
Data Source: BioPlex
THADA
Tbio
Novelty: 0.06983966
p_int: 0.99831819
p_ni: 0.00168181
Data Source: BioPlex
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
p_int: 0.997624847
p_ni: 0.002373546
p_wrong: 0.000001607
Data Source: BioPlex
XPO6
Tbio
Novelty: 0.03229708
p_int: 0.997547629
p_ni: 0.00245237
Data Source: BioPlex
XPO4
Tbio
Novelty: 0.01507446
p_int: 0.996145393
p_ni: 0.003854607
Data Source: BioPlex
HTT
Tchem
Novelty: 0.00034051
p_int: 0.996145315
p_ni: 0.003854685
Score: 0.219
Data Source: BioPlex,STRINGDB
BRAT1
Tbio
Novelty: 0.04039173
p_int: 0.995213743
p_ni: 0.004786256
Data Source: BioPlex
MZT2B
Tdark
Novelty: 0.69469786
p_int: 0.994954521
p_ni: 0.004100907
p_wrong: 0.000944572
Data Source: BioPlex
TUBGCP2
Tbio
Novelty: 0.01856674
p_int: 0.994884016
p_ni: 0.005115984
Data Source: BioPlex
Publication Statistics
PubMed Score  2654.46

PubMed score by year
PubTator Score  1250.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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