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Tbio
GDI1
Rab GDP dissociation inhibitor alpha

Protein Summary
Description
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000447750
  • ENSP00000394071
  • ENSG00000203879

Symbol
  • GDIL
  • OPHN2
  • RABGDIA
  • XAP4
  • 1A
  • GDIL
  • MRX41
  • MRX48
  • OPHN2
  • XAP-4
  • RABGD1A
  • RABGDIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.94
kinase perturbation
0.76
interacting protein
0.69
tissue
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.48   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.48   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
15.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
15.2
Pathways (10)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Rho GTPase cycle
Signal Transduction
Protein-Protein Interactions (205)
1 – 10 of 205
RAB9A
Tbio
Family: Enzyme
Novelty: 0.07006531
p_int: 0.999999999
p_ni: 1e-9
Score: 0.976
Data Source: BioPlex,Reactome,STRINGDB
RAB22A
Tbio
Family: Enzyme
Novelty: 0.02344687
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 1e-9
Score: 0.811
Data Source: BioPlex,STRINGDB
RAB12
Tbio
Family: Enzyme
Novelty: 0.05361391
p_int: 0.999999989
p_ni: 3e-9
p_wrong: 8e-9
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
RAB24
Tbio
Family: Enzyme
Novelty: 0.04382232
p_int: 0.999999986
p_ni: 2e-9
p_wrong: 1.2e-8
Score: 0.606
Data Source: BioPlex,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.06230082
p_int: 0.99999997
p_ni: 3e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
RAB4A
Tbio
Family: Enzyme
Novelty: 0.00423197
p_int: 0.999999801
p_ni: 1.99e-7
Score: 0.662
Data Source: BioPlex,STRINGDB
RAB8A
Tbio
Family: Enzyme
Novelty: 0.00486694
p_int: 0.999999788
p_ni: 2.12e-7
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
USP25
Tbio
Family: Enzyme
Novelty: 0.03671706
p_int: 0.999999767
p_ni: 2.33e-7
Score: 0.167
Data Source: BioPlex,STRINGDB
RAB34
Tbio
Family: Enzyme
Novelty: 0.03645677
p_int: 0.999999695
p_ni: 3.02e-7
p_wrong: 3e-9
Score: 0.565
Data Source: BioPlex,STRINGDB
RASEF
Tbio
Novelty: 0.08877022
p_int: 0.999999466
p_ni: 7.3e-8
p_wrong: 4.61e-7
Score: 0.551
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  57.48

PubMed score by year
PubTator Score  33.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer